PMID- 37881186
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 14
DP  - 2023
TI  - Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in 
      healthy and type 2 diabetic rats.
PG  - 1214658
LID - 10.3389/fphar.2023.1214658 [doi]
LID - 1214658
AB  - Objective: This study aimed to investigate effect of antidiabetic herb Astragali 
      Radix (AR) on pharmacokinetic behavior of dapagliflozin (DAPA) in healthy rats 
      and type 2 diabetes mellitus (T2DM) rats. Methods: The T2DM rats were induced by 
      high-fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). 
      Concentrations of DAPA in healthy and T2DM rat plasma were determined by 
      UPLC-MS/MS method. Effect of AR extract (ARE) on pharmacokinetic behavior of DAPA 
      in healthy and T2DM rats was evaluated, respectively. Results: The diabetes 
      status and co-administrated with ARE significantly affected pharmacokinetic 
      behaviors of DAPA in the rats. Compared to that in healthy rats, t (max) of DAPA 
      significantly shortened, its C (max) significantly increased in T2DM rats, and 
      its t (1/2), V, AUC, CL and MRT kept unchanged. When ARE was co-administrated 
      with DAPA, C (max) of DAPA significantly increased, its t (max) and MRT 
      significantly decreased, and its t (1/2), V, AUC and CL kept unchanged in healthy 
      rats. t (max) and C (max) of DAPA significantly decreased, its t (1/2) and V 
      significantly increased, and its AUC, CL and MRT were unchanged in T2DM rats when 
      ARE was co-administrated with DAPA. Co-administration of DAPA and ARE promoted 
      absorptive rate of DAPA, increased its extravascular tissue distribution, and 
      prolonged its duration of action. ARE did not cause accumulation of DAPA in vivo. 
      Conclusion: Both disease status of T2DM and co-administration of ARE affect 
      pharmacokinetic behavior of DAPA in vivo. Potential pharmacokinetic interactions 
      may occur in vivo when herbs and drugs are co-administrated, which may affect 
      efficacy and safety of drugs.
CI  - Copyright (c) 2023 Du, Hu, Liang, Yang, Fang and Ma.
FAU - Du, Wandi
AU  - Du W
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Hu, Jiarong
AU  - Hu J
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Liang, Jingru
AU  - Liang J
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Yang, Xiaolei
AU  - Yang X
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Fang, Boyu
AU  - Fang B
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
FAU - Ma, Guo
AU  - Ma G
AD  - Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20231010
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC10597649
OTO - NOTNLM
OT  - Astragali radix
OT  - Astragali radix extract
OT  - UPLC-MS/MS
OT  - dapagliflozin
OT  - pharmacokinetics
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/26 06:42
MHDA- 2023/10/26 06:43
PMCR- 2023/10/10
CRDT- 2023/10/26 04:02
PHST- 2023/04/30 00:00 [received]
PHST- 2023/09/22 00:00 [accepted]
PHST- 2023/10/26 06:43 [medline]
PHST- 2023/10/26 06:42 [pubmed]
PHST- 2023/10/26 04:02 [entrez]
PHST- 2023/10/10 00:00 [pmc-release]
AID - 1214658 [pii]
AID - 10.3389/fphar.2023.1214658 [doi]
PST - epublish
SO  - Front Pharmacol. 2023 Oct 10;14:1214658. doi: 10.3389/fphar.2023.1214658. 
      eCollection 2023.