PMID- 37882478
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Feb
TI  - Associations of concurrent early-life famine exposure and adulthood obesity with 
      type 2 diabetes mellitus in middle-aged Chinese.
PG  - e13480
LID - 10.1111/1753-0407.13480 [doi]
LID - e13480
AB  - BACKGROUND: Evidence has shown that early-life famine exposure and obesity in 
      adulthood are independently associated with the risk of type 2 diabetes mellitus 
      (T2DM). However, few studies had revealed the combined effect of these risk 
      factors. METHODS: Two sets of groups from the China Health and Retirement 
      Longitudinal Study (CHARLS) were selected. The fetal-exposure group born in 
      1959-1961 from 2011 wave (N = 958) and nonexposure group born in 1963-1965 from 
      2015 wave (N = 1540) were selected as Comparison 1. The early childhood-exposure 
      group born in 1955-1957 from 2011 wave (N = 1510) and fetal-exposure group born 
      in 1959-1961 from 2015 wave (N = 943) were Comparison 2. Logistic regressions 
      were applied to examine the associations of different famine exposure periods and 
      obesity patterns with T2DM risk. RESULTS: Compared with nonexposed participants 
      without central overweight/obesity in adulthood, central overweight/obesity in 
      adulthood together with nonexposure (odds ratio [OR]: 1.89, 95% confidence 
      interval [CI]: 1.19-3.00) or fetal-exposure (OR: 1.99, 95% CI: 1.23-3.23) was 
      associated with higher risks of T2DM. Compared with the early childhood-exposure 
      group, the fetal-exposed participants showed higher risks of T2DM (OR: 1.30, 95% 
      CI: 1.02-1.66). The coexistence of fetal famine exposure and central 
      overweight/obesity in adulthood was associated with higher risks of T2DM (OR: 
      1.82, 95% CI: 1.19-2.79). Consistent associations were observed among males and 
      participants from less severely affected areas. CONCLUSIONS: In conclusion, 
      central overweight/obesity in adulthood is associated with the increased risk of 
      T2DM, but the effect of early-life famine exposure is not very clear.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Yi, Qian
AU  - Yi Q
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wu, Jing
AU  - Wu J
AUID- ORCID: 0009-0001-4400-0577
AD  - School of Public Health, Zhejiang University School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Shen, Yaojia
AU  - Shen Y
AD  - Department of Maternal and Child Health, School of Public Health, Peking 
      University, Beijing, China.
FAU - Zhu, Yunying
AU  - Zhu Y
AD  - School of Public Health, Zhejiang University School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Zhou, Yiyang
AU  - Zhou Y
AD  - School of Public Health, Zhejiang University School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Bai, He
AU  - Bai H
AD  - School of Public Health, Zhejiang University School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Hao, Jiajun
AU  - Hao J
AD  - School of Public Health, Zhejiang University School of Medicine, Zhejiang 
      University, Hangzhou, China.
FAU - Song, Peige
AU  - Song P
AUID- ORCID: 0000-0002-0196-9759
AD  - School of Public Health and Women's Hospital, Zhejiang University School of 
      Medicine, Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20231026
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Male
MH  - Middle Aged
MH  - Humans
MH  - Child, Preschool
MH  - Aged
MH  - Female
MH  - *Diabetes Mellitus, Type 2/etiology/complications
MH  - Famine
MH  - Longitudinal Studies
MH  - Overweight/complications
MH  - *Starvation/complications/epidemiology
MH  - Obesity/epidemiology/complications
MH  - Risk Factors
MH  - Obesity, Abdominal/complications
MH  - China/epidemiology
MH  - *Prenatal Exposure Delayed Effects/epidemiology/etiology
PMC - PMC10859315
OTO - NOTNLM
OT  - famine
OT  - obesity
OT  - overweight
OT  - type 2 diabetes mellitus
EDAT- 2023/10/26 12:43
MHDA- 2024/02/12 15:42
PMCR- 2023/10/26
CRDT- 2023/10/26 08:23
PHST- 2023/09/04 00:00 [revised]
PHST- 2023/03/20 00:00 [received]
PHST- 2023/09/11 00:00 [accepted]
PHST- 2024/02/12 15:42 [medline]
PHST- 2023/10/26 12:43 [pubmed]
PHST- 2023/10/26 08:23 [entrez]
PHST- 2023/10/26 00:00 [pmc-release]
AID - JDB13480 [pii]
AID - 10.1111/1753-0407.13480 [doi]
PST - ppublish
SO  - J Diabetes. 2024 Feb;16(2):e13480. doi: 10.1111/1753-0407.13480. Epub 2023 Oct 
      26.