PMID- 37883370
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231101
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 10
DP  - 2023
TI  - Health-related quality of life and its associated factors in patients with 
      chronic obstructive pulmonary disease.
PG  - e0293342
LID - 10.1371/journal.pone.0293342 [doi]
LID - e0293342
AB  - OBJECTIVE: The present study aimed to evaluate HRQOL and to explore the factors 
      associated with poor HRQOL among patients with COPD. METHODS: In the present 
      cross-sectional study, the validated St George's Respiratory Questionnaire for 
      COPD patients (SGRQ-C) was used to evaluate HRQOL among 702 patients with COPD at 
      two major hospitals in Jordan in the period between January and April 2022. 
      Quantile regression analysis was used to explore the factors associated with 
      HRQOL among the study participants. RESULTS: According to SGRQ-C, the HRQOL of 
      the study participants was greatly impaired with a total SGRQ of 55.2 (34-67.8). 
      The highest impairment in the HRQOL was in the impact domain with a median of 
      58.7 (29-76.3). Increased number of prescribed medications (beta = 1.157, P<0.01), 
      older age (beta = 0.487, P<0.001), male gender (beta = 5.364, P<0.01), low education 
      level (beta = 9.313, P<0.001), low and moderate average income (beta = 6.440, P<0.05, 
      and beta = 6.997, P<0.01, respectively) were associated with poorer HRQOL. On the 
      other hand, being married (beta = -17.122, P<0.001), living in rural area (beta = 
      -6.994, P<0.01), non-use of steroids inhalers (beta = -3.859, P<0.05), not receiving 
      long acting muscarinic antagonists (LAMA) (beta = -9.269, P<0.001), not receiving 
      LABA (beta = -8.243, P<0.001) and being adherent to the prescribed medications (beta = 
      -6.016, P<0.001) were associated with improved HRQOL. Furthermore, lower disease 
      severity (stage A, B, and C) (beta = -23.252, -10.389, and -9.696 respectively, 
      P<0.001), and the absence of comorbidities (beta = -14.303, P<0.001) were associated 
      with better HRQOL. CONCLUSIONS: In order to maximize HRQOL in patients with COPD, 
      future COPD management interventions should adopt a multidisciplinary approach 
      involving different healthcare providers, which aims to provide patient-centered 
      care, implement personalized interventions, and improve medication adherence, 
      particularly for patients who are elderly, males, have low socioeconomic status, 
      receive multiple medications and have multiple comorbid diseases.
CI  - Copyright: (c) 2023 Jarab et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Jarab, Anan S
AU  - Jarab AS
AUID- ORCID: 0000-0002-0416-506X
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
AD  - College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
FAU - Al-Qerem, Walid
AU  - Al-Qerem W
AD  - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, 
      Amman, Jordan.
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
AUID- ORCID: 0000-0002-2808-5099
AD  - Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, 
      University of Sharjah, Sharjah, United Arab Emirates.
AD  - Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
FAU - Abu Heshmeh, Shrouq
AU  - Abu Heshmeh S
AUID- ORCID: 0000-0002-6734-9624
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Mukattash, Tareq L
AU  - Mukattash TL
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Naser, Abdallah Y
AU  - Naser AY
AUID- ORCID: 0000-0001-8440-7446
AD  - Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of 
      Pharmacy, Isra University, Amman, Jordan.
FAU - Al Hamarneh, Yazid N
AU  - Al Hamarneh YN
AD  - Department of Pharmacology, Faculty of Medicine and Dentistry, University of 
      Alberta, Edmonton, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231026
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - Pulmonary Disease, Chronic Obstructive, Severe Early-Onset
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - Quality of Life
MH  - Cross-Sectional Studies
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Comorbidity
MH  - *Asthma
PMC - PMC10602230
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/10/26 18:43
MHDA- 2023/10/30 06:46
PMCR- 2023/10/26
CRDT- 2023/10/26 13:35
PHST- 2023/06/21 00:00 [received]
PHST- 2023/10/10 00:00 [accepted]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/10/26 18:43 [pubmed]
PHST- 2023/10/26 13:35 [entrez]
PHST- 2023/10/26 00:00 [pmc-release]
AID - PONE-D-23-19403 [pii]
AID - 10.1371/journal.pone.0293342 [doi]
PST - epublish
SO  - PLoS One. 2023 Oct 26;18(10):e0293342. doi: 10.1371/journal.pone.0293342. 
      eCollection 2023.