PMID- 37883776
OWN - NLM
STAT- Publisher
LR  - 20231026
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
DP  - 2023 Oct 27
TI  - Correlating Blood Selenium Levels in Type 2 Diabetes Mellitus with Peripheral 
      Neuropathy and Factors Contributing to Associated Lesion Development.
LID - AT9374 [pii]
AB  - BACKGROUND: Diabetic peripheral neuropathy (DPN) is a prevalent complication of 
      type 2 diabetes mellitus (T2DM). A comprehensive understanding of DPN's causal 
      factors is pivotal for effective prevention and treatment, but the precise 
      clinical pathogenesis remains unclear. OBJECTIVE: To investigate the correlation 
      between blood selenium (Se) levels and DPN in T2DM patients and analyze factors 
      contributing to lesion development. METHODS: We selected 51 patients with DPN and 
      57 with T2DM alone between June 2021 and August 2022. Blood glucose, lipid, and 
      Se levels were assessed. Electromyographic evoked potentials measured motor nerve 
      conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) in DPN 
      patients. RESULTS: DPN patients exhibited lower Se, MNCV, and SNCV compared to DM 
      patients, with higher glucose and lipid levels (P < .05). Logistic regression 
      analysis identified age (95%CI 1.256-9.631), disease duration (95%CI 
      2.160-11.816), fasting blood glucose (95%CI 2.160-11.816), and HbA1c (95%CI 
      1.064-7.632) as independent risk factors for DPN in T2DM, while Se (95%CI 
      0.324-1.126) emerged as an independent protective factor (P < .05). CONCLUSIONS: 
      Blood selenium levels and DPN are closely related, with selenium emerging as a 
      significant factor in DPN occurrence among T2DM patients.
FAU - Xu, Hui
AU  - Xu H
FAU - Wen, Qian
AU  - Wen Q
FAU - Ye, Mao
AU  - Ye M
LA  - eng
PT  - Journal Article
DEP - 20231027
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
SB  - IM
EDAT- 2023/10/26 18:42
MHDA- 2023/10/26 18:42
CRDT- 2023/10/26 16:32
PHST- 2023/10/26 18:42 [medline]
PHST- 2023/10/26 18:42 [pubmed]
PHST- 2023/10/26 16:32 [entrez]
AID - AT9374 [pii]
PST - aheadofprint
SO  - Altern Ther Health Med. 2023 Oct 27:AT9374.