PMID- 37884074 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20240218 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 240 IP - Pt 2 DP - 2024 Jan 1 TI - Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort. PG - 117496 LID - S0013-9351(23)02300-9 [pii] LID - 10.1016/j.envres.2023.117496 [doi] AB - BACKGROUND: Ambient fine particulate matter (PM(2.5)) exposure has been related to cardiometabolic diseases, but the underlying biological pathways remain unclear at the population level. OBJECTIVE: To investigate the effect of PM(2.5) exposure on changes in multiple cardiometabolic biomarkers across different exposure durations. METHOD: Data from a prospective cohort study were analyzed. Ten cardiometabolic biomarkers were measured, including ghrelin, resistin, leptin, C-peptide, creatine kinase myocardial band (CK-MB), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), N-terminal pro B-type natriuretic peptide (NT-proBNP), troponin, and interleukin-6 (IL-6). PM(2.5) levels across exposure durations from 1 to 36 months were assessed. Mixed effect model was used to estimate changes in biomarker levels against 1 mug/m(3) increase in PM(2.5) level across different exposure durations. RESULTS: Totally, 641 participants were included. The average PM(2.5) exposure level was 9 mug/m(3). PM(2.5) exposure was inversely associated with ghrelin, and positively associated with all other biomarkers. The magnitudes of these associations were duration-sensitive and exhibited a U-shaped or inverted-U-shaped trend. For example, the association of resistin were beta = 0.05 (95% CI: 0.00, 0.09) for 1-month duration, strengthened to beta = 0.27 (95% CI: 0.14, 0.41) for 13-month duration, and weakened to beta = 0.12 (95% CI: -0.03, 0.26) for 24-month duration. Similar patterns were observed for other biomarkers except for CK-MB, of which the association direction switched from negative to positive as the duration increased. Resistin, leptin, MCP-1, TNF-alpha, and troponin had a sensitive exposure duration of nearly 12 months. Ghrelin and C-peptide were more sensitive to longer-term exposure (>18 months), while NT-proBNP and IL-6 were more sensitive to shorter-term exposure (<6 months). CONCLUSION: PM(2.5) exposure was associated with elevated levels in cardiometabolic biomarkers related to insulin resistance, inflammation, and heart injury. The magnitudes of these associations depended on the exposure duration. The most sensitive exposure durations of different biomarkers varied. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Luo, Jiajun AU - Luo J AD - Department of Public Health Sciences, The University of Chicago, United States; Institute for Population and Precision Health, The University of Chicago, United States. FAU - Kibriya, Muhammad G AU - Kibriya MG AD - Department of Public Health Sciences, The University of Chicago, United States; Institute for Population and Precision Health, The University of Chicago, United States. FAU - Jasmine, Farzana AU - Jasmine F AD - Institute for Population and Precision Health, The University of Chicago, United States. FAU - Shaikh, Afzal AU - Shaikh A AD - Institute for Population and Precision Health, The University of Chicago, United States. FAU - Jin, Zhihao AU - Jin Z AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, United States. FAU - Sargis, Robert AU - Sargis R AD - College of Medicine, University of Illinois Chicago, United States. FAU - Kim, Karen AU - Kim K AD - Department of Medicine, The University of Chicago, United States. FAU - Olopade, Christopher O AU - Olopade CO AD - Department of Medicine, The University of Chicago, United States. FAU - Pinto, Jayant AU - Pinto J AD - Department of Medicine, The University of Chicago, United States. FAU - Ahsan, Habibul AU - Ahsan H AD - Department of Public Health Sciences, The University of Chicago, United States; Institute for Population and Precision Health, The University of Chicago, United States. FAU - Aschebrook-Kilfoy, Briseis AU - Aschebrook-Kilfoy B AD - Department of Public Health Sciences, The University of Chicago, United States; Institute for Population and Precision Health, The University of Chicago, United States. Electronic address: brisa@uchicago.edu. LA - eng GR - P30 ES027792/ES/NIEHS NIH HHS/United States GR - U2R TW010122/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20231024 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Air Pollutants) RN - 0 (Leptin) RN - 0 (Ghrelin) RN - 0 (Resistin) RN - 0 (C-Peptide) RN - 0 (Interleukin-6) RN - 0 (Tumor Necrosis Factor-alpha) RN - 0 (Particulate Matter) RN - 0 (Biomarkers) RN - 0 (Troponin) SB - IM MH - Humans MH - *Air Pollutants/analysis MH - Leptin MH - Ghrelin MH - Resistin MH - Prospective Studies MH - Black or African American MH - C-Peptide MH - Interleukin-6 MH - Tumor Necrosis Factor-alpha MH - *Air Pollution MH - Particulate Matter/toxicity/analysis MH - Biomarkers MH - *Cardiovascular Diseases/epidemiology MH - Troponin MH - Environmental Exposure PMC - PMC10872637 MID - NIHMS1943646 COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/27 00:43 MHDA- 2023/11/27 12:42 PMCR- 2025/01/01 CRDT- 2023/10/26 19:19 PHST- 2023/06/25 00:00 [received] PHST- 2023/10/20 00:00 [revised] PHST- 2023/10/23 00:00 [accepted] PHST- 2025/01/01 00:00 [pmc-release] PHST- 2023/11/27 12:42 [medline] PHST- 2023/10/27 00:43 [pubmed] PHST- 2023/10/26 19:19 [entrez] AID - S0013-9351(23)02300-9 [pii] AID - 10.1016/j.envres.2023.117496 [doi] PST - ppublish SO - Environ Res. 2024 Jan 1;240(Pt 2):117496. doi: 10.1016/j.envres.2023.117496. Epub 2023 Oct 24.