PMID- 37884126
OWN - NLM
STAT- MEDLINE
DCOM- 20231219
LR  - 20240111
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 75
IP  - 6
DP  - 2023 Nov-Dec
TI  - Prevalence of cardiac abnormalities and heart failure in unselected out-patients 
      with type 2 diabetes mellitus and associated clinical factors: Real-world 
      evidence from an Indian registry.
PG  - 436-442
LID - S0019-4832(23)00167-0 [pii]
LID - 10.1016/j.ihj.2023.10.003 [doi]
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is known to be associated with 
      development of left ventricular (LV) dysfunction and heart failure (HF). The 
      study aimed to determine the prevalence of LV dysfunction and HF in unselected 
      out-patients with T2DM with no previous cardiac history and to correlate LV 
      dysfunction and HF with demographic and comorbid characteristics. METHODS: This 
      cross-sectional study conducted at 27 centers in India captured demographic and 
      clinical data through electronic case record forms. B-type natriuretic peptide of 
      >105 pg/mL was used to diagnose HF and two-dimensional echocardiography was used 
      to assess LV dysfunction. RESULTS: Of the 615 patients, 54.3 % (n = 334) were 
      males; mean age was 57.4 +/- 10.48 years. More than one-third of the patients had 
      T2DM duration of >10 years (n = 238; 38.7 %), with hypertension as the most 
      prevalent comorbidity (n = 372, 78.6 %). Approximately 61.3 % of the patients had 
      LV hypertrophy. The mean LV mass was 135.0 +/- 56.16 g (95 % CI 130.28, 139.70). 
      The prevalence of any type of LV dysfunction, including systolic or diastolic 
      dysfunction and HF was 55 % (95 % CI 51.0, 59.0) and 10 % (95 % CI 7.0, 12.0), 
      respectively. A negligible but statistically significant correlation was observed 
      between LV dysfunction and T2DM duration (p = 0.011), alongside HF and age 
      (p < 0.0001). CONCLUSION: Real-world data from this registry from India 
      demonstrates a substantial burden of LV dysfunction and HF in individuals with 
      T2DM in India. It is imperative to formulate strategies for early identification 
      of LV dysfunction in individuals with T2DM for prevention and consequent 
      management of HF.
CI  - Copyright (c) 2023. Published by Elsevier, a division of RELX India, Pvt. Ltd.
FAU - Rajput, Rajesh
AU  - Rajput R
AD  - PGIMS, Rohtak, India.
FAU - Mohan, J C
AU  - Mohan JC
AD  - Institute of Heart & Vascular Diseases, Jaipur Golden Hospital, Sector 3, Rohini, 
      New Delhi, India. Electronic address: a51hauzkhas@gmail.com.
FAU - Sawhney, J P S
AU  - Sawhney JPS
AD  - Sir Ganga Ram Hospital, Delhi, India.
FAU - Dalal, Jamshed
AU  - Dalal J
AD  - Kokilaben Dhirubhai Ambani Hospital, Mumbai, India.
FAU - Mullasari, Ajit
AU  - Mullasari A
AD  - MMM Hospital, Chennai, India.
FAU - Vasnawala, Hardik
AU  - Vasnawala H
AD  - Medical Affairs, AstraZeneca Pharma India Ltd, India.
FAU - Kumar, Amit
AU  - Kumar A
AD  - Medical Affairs, AstraZeneca Pharma India Ltd, India.
FAU - Hs, Bharath
AU  - Hs B
AD  - Medical Affairs, AstraZeneca Pharma India Ltd, India.
FAU - Sarda, Shital
AU  - Sarda S
AD  - Medical Affairs, AstraZeneca Pharma India Ltd, India.
LA  - eng
PT  - Journal Article
DEP - 20231024
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/diagnosis
MH  - Outpatients
MH  - Prevalence
MH  - Cross-Sectional Studies
MH  - *Heart Failure/diagnosis/epidemiology/drug therapy
MH  - *Ventricular Dysfunction, Left/diagnosis/epidemiology/etiology
MH  - Ventricular Function, Left
PMC - PMC10774570
OTO - NOTNLM
OT  - 2-D echocardiography
OT  - Heart failure
OT  - Left ventricular dysfunction
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/27 00:43
MHDA- 2023/12/19 06:42
PMCR- 2023/11/01
CRDT- 2023/10/26 19:21
PHST- 2023/07/28 00:00 [received]
PHST- 2023/09/05 00:00 [revised]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2023/12/19 06:42 [medline]
PHST- 2023/10/27 00:43 [pubmed]
PHST- 2023/10/26 19:21 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - S0019-4832(23)00167-0 [pii]
AID - 10.1016/j.ihj.2023.10.003 [doi]
PST - ppublish
SO  - Indian Heart J. 2023 Nov-Dec;75(6):436-442. doi: 10.1016/j.ihj.2023.10.003. Epub 
      2023 Oct 24.