PMID- 37885097
OWN - NLM
STAT- MEDLINE
DCOM- 20231031
LR  - 20231105
IS  - 2639-9636 (Print)
IS  - 2639-9636 (Linking)
VI  - 38
IP  - 11
DP  - 2023 Nov 1
TI  - Comparing Safety and Effectiveness of Antiretroviral Therapy in a Diverse 
      Population of Older People With HIV.
PG  - 472-485
LID - 10.4140/TCP.n.2023.472 [doi]
AB  - Background Advances in antiretroviral therapy (ART) enable people with HIV to 
      live longer, healthier lives. However, older people with HIV (OPWH) are more 
      susceptible to long-term toxicity and drug interactions associated with ART. 
      Racial and ethnic minorities have specific social determinants of health, which 
      increase their risks of negative outcomes. Objective To determine if there were 
      differences in the safety and effectiveness of ART in White, Black, and Hispanic 
      OPWH. Methods A retrospective observational study was conducted on patients 
      receiving care between January 1, 2017, and December 31, 2022, at two affiliated 
      HIV clinics in South Florida. The primary effectiveness endpoint was the 
      percentage of OPWH with undetectable viral load (< 50 copies/mL) throughout the 
      study. Secondary safety endpoints were changes in median metabolic, hepatic, and 
      renal parameters. A two-way analysis of variance or the Chi-square test was used 
      to determine differences between groups. Results A total of 116 White, 42 Black, 
      and 40 Hispanic OPWH were included. Upon enrollment, most patients (90.7%) were 
      receiving ART. Of these, the percentage with undetectable viral load was lower 
      among Black (61.8%) compared with White (85.8%; P < 0.01) or Hispanic (83.3%; P < 
      0.05) patients. Similarly, throughout the study after the first visit, the 
      percentage with undetectable viral load was lower among Black (61.6%) compared 
      with White (84.7%; P < 0.05) or Hispanic (83.3%; P = 0.12) patients. However, 
      there were no significant differences in the percentage of virally suppressed (< 
      200 copies/mL) participants throughout the study after the first visit between 
      Black (88.5%), White (94.9%), and Hispanic (96.7%) patients. Additionally, no 
      significant changes in safety endpoints were observed among the groups throughout 
      the study. Conclusion Fewer Black OPWH had undetectable viral load upon 
      enrollment and throughout the study compared with White or Hispanic OPWH, 
      suggesting the need to provide more targeted interventions for Black patients.
FAU - Chahine, Elias B
AU  - Chahine EB
AD  - 1Palm Beach Atlantic University Gregory School of Pharmacy, West Palm Beach, 
      Florida.
FAU - Nunez-Medina, Ricardo M
AU  - Nunez-Medina RM
AD  - 1Palm Beach Atlantic University Gregory School of Pharmacy, West Palm Beach, 
      Florida.
FAU - Williams, Kiara
AU  - Williams K
AD  - 1Palm Beach Atlantic University Gregory School of Pharmacy, West Palm Beach, 
      Florida.
FAU - Kuretski, Jennifer
AU  - Kuretski J
AD  - 2Palm Beach Atlantic University School of Nursing, West Palm Beach, Florida.
FAU - Maarsingh, Harm
AU  - Maarsingh H
AD  - 1Palm Beach Atlantic University Gregory School of Pharmacy, West Palm Beach, 
      Florida.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Sr Care Pharm
JT  - The Senior care pharmacist
JID - 101737969
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Hispanic or Latino
MH  - HIV
MH  - *HIV Infections/drug therapy/epidemiology
MH  - Racial Groups
MH  - Retrospective Studies
MH  - White
MH  - Black or African American
MH  - *Anti-Retroviral Agents/therapeutic use
EDAT- 2023/10/27 06:42
MHDA- 2023/10/30 06:47
CRDT- 2023/10/27 00:32
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/27 06:42 [pubmed]
PHST- 2023/10/27 00:32 [entrez]
AID - 10.4140/TCP.n.2023.472 [doi]
PST - ppublish
SO  - Sr Care Pharm. 2023 Nov 1;38(11):472-485. doi: 10.4140/TCP.n.2023.472.