PMID- 37885940
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231028
IS  - 0970-9134 (Print)
IS  - 0973-7723 (Electronic)
IS  - 0970-9134 (Linking)
VI  - 39
IP  - 6
DP  - 2023 Nov
TI  - Cell sheet transplantation for ischemic heart disease: a systematic review.
PG  - 577-587
LID - 10.1007/s12055-023-01554-z [doi]
AB  - OBJECTIVE: Cell sheet transplantation is emerging as an appealing alternative for 
      ischemic heart disease patients as it potentially can increase stem cell 
      viability and retention. But the outcomes and safety of this treatment are still 
      limited in literature and the result varies widely. We conduct a systematic 
      review to look at the efficacy and safety of this promising transplantation 
      method. METHODS: A systematic review was performed according to PRISMA 
      guidelines. A comprehensive literature search was undertaken using the PubMed, 
      Scopus, and Embase databases. Articles were thoroughly evaluated and analyzed. 
      RESULTS: Seven publications about cell sheet transplantation for ischemic heart 
      disease patients were included. The primary outcomes measured were left 
      ventricular ejection fraction (LVEF) and New York Heart Association (NYHA) class. 
      Safety measurement was depicted by cardiac-related readmission and deaths. The 
      follow-up time ranged from 3 to 36 months for clinical outcomes and 8.5 years for 
      safety outcomes. Cell sheet transplantation showed improvement in LVEF and NYHA 
      class in most studies. Cardiac-related readmission and adverse events of cell 
      sheet transplantation range from 0 to 30.4%, all were nonfatal as no 
      cardiac-related death was reported. Patient preoperative status seems can affect 
      the patient's response to cell sheet therapy. CONCLUSION: Cell sheet 
      transplantation can safely improve LVEF and NYHA class in ischemic heart disease 
      patients, even in very low ejection fraction patients with unsuccessful standard 
      therapy before. Further studies with better patient inclusion, larger population, 
      and long-term follow-up required to confirm these results.
CI  - (c) Indian Association of Cardiovascular-Thoracic Surgeons 2023. Springer Nature or 
      its licensor (e.g. a society or other partner) holds exclusive rights to this 
      article under a publishing agreement with the author(s) or other rightsholder(s); 
      author self-archiving of the accepted manuscript version of this article is 
      solely governed by the terms of such publishing agreement and applicable law.
FAU - Thamrin, Ahmad Muslim Hidayat
AU  - Thamrin AMH
AD  - Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular 
      Surgery, Harapan Kita National Cardiovascular Center Hospital, S. Parman Street 
      Cavling 87, Jakarta, Indonesia.
AD  - Faculty of Medicine Syarif Hidayatullah State Islamic University - Haji Hospital, 
      Jakarta, Indonesia. GRID: grid.449547.f. ISNI: 0000 0000 9331 2695
FAU - Soetisna, Tri Wisesa
AU  - Soetisna TW
AUID- ORCID: 0000-0002-7428-3600
AD  - Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular 
      Surgery, Harapan Kita National Cardiovascular Center Hospital, S. Parman Street 
      Cavling 87, Jakarta, Indonesia.
AD  - Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, 
      University of Indonesia, Jakarta, Indonesia. ROR: https://ror.org/0116zj450. 
      GRID: grid.9581.5. ISNI: 0000 0001 2019 1471
FAU - Ramadhani, Andi Nurul Erisya
AU  - Ramadhani ANE
AD  - Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular 
      Surgery, Harapan Kita National Cardiovascular Center Hospital, S. Parman Street 
      Cavling 87, Jakarta, Indonesia.
FAU - Hendarto, Hari
AU  - Hendarto H
AD  - Faculty of Medicine Syarif Hidayatullah State Islamic University - Haji Hospital, 
      Jakarta, Indonesia. GRID: grid.449547.f. ISNI: 0000 0000 9331 2695
LA  - eng
PT  - Journal Article
DEP - 20230717
PL  - India
TA  - Indian J Thorac Cardiovasc Surg
JT  - Indian journal of thoracic and cardiovascular surgery
JID - 8700105
PMC - PMC10597942
OTO - NOTNLM
OT  - Cell sheet transplantation
OT  - Ischemic heart disease
OT  - Outcome
OT  - Safety
OT  - Stem cell
COIS- Conflict of interestThe authors declare no competing interests.
EDAT- 2023/10/27 06:42
MHDA- 2023/10/27 06:43
PMCR- 2024/11/01
CRDT- 2023/10/27 04:27
PHST- 2023/03/15 00:00 [received]
PHST- 2023/05/30 00:00 [revised]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2024/11/01 00:00 [pmc-release]
PHST- 2023/10/27 06:43 [medline]
PHST- 2023/10/27 06:42 [pubmed]
PHST- 2023/10/27 04:27 [entrez]
AID - 1554 [pii]
AID - 10.1007/s12055-023-01554-z [doi]
PST - ppublish
SO  - Indian J Thorac Cardiovasc Surg. 2023 Nov;39(6):577-587. doi: 
      10.1007/s12055-023-01554-z. Epub 2023 Jul 17.