PMID- 37888661 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231029 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 11 IP - 10 DP - 2023 Sep 25 TI - Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women. LID - 10.3390/toxics11100810 [doi] LID - 810 AB - Cumulative evidence has demonstrated that exposure to polycyclic aromatic hydrocarbons (PAHs) or phthalates (PAEs) contributes to a variety of adverse health effects. However, the association of PAHs and PAEs co-exposure with blood cell-based inflammatory indicators during early pregnancy is still unclear. We aimed to investigate the single and mixed associations of exposure to PAHs and PAEs with blood cell-based inflammatory indicators among early pregnant women. A total of 318 early pregnant women were included in this study. General linear regressions were used to estimate the relationships of individual OH-PAHs and mPAEs with blood cell-based inflammatory indicators. The key pollutants were selected by an adapted least absolute shrinkage and selection operator (LASSO) penalized regression model and wasemployed to build the Bayesian kernel machine regression (BKMR) and quantile g-computation (Q-g) models, which can assess the joint association of OH-PAHs and mPAEs with blood cell-based inflammatory indicators. General linear regression indicated that each 1% increase in MOP was associated with a 4.92% (95% CI: 2.12%, 7.68%), 3.25% (95% CI: 0.50%, 6.18%), 5.87% (95% CI: 2.22%, 9.64%), and 6.50% (95% CI: 3.46%, 9.64%) increase in WBC, lymphocytes, neutrophils, and monocytes, respectively. BKMR and Q-g analysis showed that the mixture of OH-PAHs and mPAEs was linked with increased levels of white blood cells (WBC), neutrophils, monocytes, and lymphocytes, and MOP was identified as the dominant contributor. OH-PAHs and mPAEs co-exposure in early pregnancy was associated with elevated blood cell-based inflammatory indicators reactions. More attention should be paid to the inflammation induced by environmental pollution for perinatal women, especially early pregnant women. FAU - Yang, Yunxiao AU - Yang Y AD - School of Nursing, Zunyi Medical University, Zunyi 563000, China. AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. FAU - Wang, Ting AU - Wang T AD - School of Health Policy and Management, Nanjing Medical University, Nanjing 210000, China. FAU - Luo, Lei AU - Luo L AUID- ORCID: 0000-0001-8235-351X AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. FAU - He, Qian AU - He Q AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China. FAU - Guo, Fangfei AU - Guo F AD - School of Public Health, Guizhou Medical University, Guiyang 550000, China. FAU - Chen, Zhongbao AU - Chen Z AD - Renhuai Center for Disease Control and Prevention, Zunyi 563000, China. FAU - Liu, Yijun AU - Liu Y AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. FAU - Liu, Xingyan AU - Liu X AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. FAU - Xie, Yan AU - Xie Y AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. FAU - Shang, Xuejun AU - Shang X AD - Department of Andrology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing 210002, China. FAU - Shen, Xubo AU - Shen X AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. FAU - Zhou, Yuanzhong AU - Zhou Y AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. FAU - Tian, Kunming AU - Tian K AD - School of Public Health, Zunyi Medical University, Zunyi 563000, China. AD - Key Laboratory of Maternal & Child Health, Exposure Science of Guizhou Higher Education Institutes, Zunyi 563000, China. LA - eng GR - the Science & Technology Program of Guizhou Province (QKHHBZ[2020]3002)/the Science & Technology Program of Guizhou Province/ GR - the Science & Technology Program of Guizhou Province (QKHPTRC-GCC[2022]039-1)/the Science & Technology Program of Guizhou Province/ GR - the Cooperative research project of Chunhui plan of Ministry of Education (HZKY20220234)/the Cooperative research project of Chunhui plan of Ministry of Education/ GR - the Science & Technology Program of Guizhou Province (QKHPTRC-CXTD[2022]014)/the Science & Technology Program of Guizhou Province/ GR - the Nature Science Foundation of Guizhou Province (QKH-J[2022]YB612)/the Nature Science Foundation of Guizhou Province/ PT - Journal Article DEP - 20230925 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC10611080 OTO - NOTNLM OT - BKMR OT - Inflammation OT - PAEs OT - PAHs OT - Q-g OT - pregnancy COIS- The authors declare no conflict of interest. EDAT- 2023/10/27 12:43 MHDA- 2023/10/27 12:44 PMCR- 2023/09/25 CRDT- 2023/10/27 07:23 PHST- 2023/08/30 00:00 [received] PHST- 2023/09/20 00:00 [revised] PHST- 2023/09/22 00:00 [accepted] PHST- 2023/10/27 12:44 [medline] PHST- 2023/10/27 12:43 [pubmed] PHST- 2023/10/27 07:23 [entrez] PHST- 2023/09/25 00:00 [pmc-release] AID - toxics11100810 [pii] AID - toxics-11-00810 [pii] AID - 10.3390/toxics11100810 [doi] PST - epublish SO - Toxics. 2023 Sep 25;11(10):810. doi: 10.3390/toxics11100810.