PMID- 37888694
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231029
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 11
IP  - 10
DP  - 2023 Oct 7
TI  - 2,4-Dichlorophenol Shows Estrogenic Endocrine Disruptor Activity by Altering Male 
      Rat Sexual Behavior.
LID - 10.3390/toxics11100843 [doi]
LID - 843
AB  - Chlorophenols (CPs) have been extensively used worldwide as a treatment to 
      prevent the growth and proliferation of different microorganisms, mainly in the 
      wood and farm industries. Chlorine has been used for water disinfection, and 
      phenol groups are water contaminants; these two groups can react with each other 
      to form species such as 2,4-dichlorophenol (2,4-DCP). 2,4-DCP is still used as an 
      herbicide in many countries such as Mexico. CPs have been largely analyzed, like 
      bisphenol A, for their probable endocrine-disrupting effects in humans and 
      aquatic animals. We still do not understand whether these endocrine responses can 
      be manifested as an impairment in sexual behavior in rodents. With the present 
      toxicology study, the endocrine-disrupting effects of 2,4-DCP on male sexual 
      behavior were investigated. Sexually naive male Wistar rats were used to assess 
      the endocrine-disrupting effects of 2,4-DCP. The rats were divided into two 
      groups: one control group and one experimental group that was administered 1.25 
      mg/day of 2,4-DCP for 45 days. After completing treatment, the male sexual 
      behavior of the rats was evaluated. The results of this investigation 
      demonstrated that 2,4-DCP affected male sexual behavior. A decrease in mount 
      latency, intromission latency, and post ejaculation period compared with the 
      control animals was found.
FAU - Ferris Pasquini, Veronica
AU  - Ferris Pasquini V
AD  - Escuela de Ciencias de la Salud, Campus Queretaro, Universidad del Valle de 
      Mexico, Queretaro 76230, Mexico.
FAU - Hurtazo, Hector
AU  - Hurtazo H
AD  - Escuela de Ciencias de la Salud, Campus Queretaro, Universidad del Valle de 
      Mexico, Queretaro 76230, Mexico.
FAU - Quintanilla, Francisco
AU  - Quintanilla F
AUID- ORCID: 0000-0001-9425-1959
AD  - Programa de Gastronomia, Facultad de Filosofia, Campus Aeropuerto, Universidad 
      Autonoma de Queretaro, Queretaro 76010, Mexico.
FAU - Cruz-Soto, Martha
AU  - Cruz-Soto M
AUID- ORCID: 0000-0001-9390-3257
AD  - Escuela de Ciencias de la Salud, Campus Queretaro, Universidad del Valle de 
      Mexico, Queretaro 76230, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20231007
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC10611086
OTO - NOTNLM
OT  - chlorophenols
OT  - endocrine disruption
OT  - estrogen activity
OT  - hormonal-induced sexual behavior
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/27 12:43
MHDA- 2023/10/27 12:44
PMCR- 2023/10/07
CRDT- 2023/10/27 07:23
PHST- 2023/08/19 00:00 [received]
PHST- 2023/09/26 00:00 [revised]
PHST- 2023/09/28 00:00 [accepted]
PHST- 2023/10/27 12:44 [medline]
PHST- 2023/10/27 12:43 [pubmed]
PHST- 2023/10/27 07:23 [entrez]
PHST- 2023/10/07 00:00 [pmc-release]
AID - toxics11100843 [pii]
AID - toxics-11-00843 [pii]
AID - 10.3390/toxics11100843 [doi]
PST - epublish
SO  - Toxics. 2023 Oct 7;11(10):843. doi: 10.3390/toxics11100843.