PMID- 37888713
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231029
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 11
IP  - 10
DP  - 2023 Oct 16
TI  - Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with 
      Liver Function during Early Pregnancy.
LID - 10.3390/toxics11100863 [doi]
LID - 863
AB  - The individual and combined associations of polycyclic aromatic hydrocarbons 
      (PAHs) metabolites on liver function during pregnancy are still lacking. We aimed 
      to explore the connection between urinary PAH metabolites and liver function in 
      early pregnant women in southwest China based on the Zunyi birth cohort. Ten 
      urinary PAH metabolites and five liver function parameters during early pregnancy 
      were measured. The associations of single PAHs with parameters of liver function 
      were assessed using multiple linear regression. A Bayesian kernel machine 
      regression (BKMR) model was used to evaluate the joint associations of the PAH 
      mixture with outcomes. We found that each 1% increment of urinary 
      2-hydroxyphenanthrene (2-OH-PHE) was associated with 3.36% (95% CI: 0.40%, 6.40%) 
      higher alanine aminotransferase (ALT) and 2.22% (95% CI: 0.80%, 3.67%) higher 
      aspartate aminotransferase (AST). Each 1% increment in 1-hydroxy-phenanthrene 
      (1-OH-PHE) was significantly associated with 7.04% (95% CI: 1.61%, 12.75%) 
      increased total bile acid (TBA). Additionally, there was a significant positive 
      linear trend between 2-OH-PHE and AST and 1-OH-PHE and TBA. BKMR also showed a 
      significant positive association of PAH mixture with AST. Our results indicate 
      that PAH metabolites were associated with increased parameters of liver function 
      among early pregnant women. Early pregnant women should pay more attention to the 
      adverse relationships between PAHs and liver function parameters to prevent 
      environment-related adverse perinatal outcomes.
FAU - Dai, Mi
AU  - Dai M
AD  - The Third Affiliated Hospital, Zunyi Medical University, Zunyi 563000, China.
FAU - Luo, Lei
AU  - Luo L
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
FAU - Xie, Caiyan
AU  - Xie C
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
FAU - Chen, Zhongbao
AU  - Chen Z
AD  - Renhuai Center for Disease Control and Prevention, Zunyi 563000, China.
FAU - Zhang, Mingzhe
AU  - Zhang M
AD  - Reproductive Center, Affiliated Hospital of Zunyi Medical University, Zunyi 
      563000, China.
FAU - Xie, Yan
AU  - Xie Y
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
FAU - Shang, Xuejun
AU  - Shang X
AD  - Department of Andrology, School of Medicine, Jinling Hospital, Nanjing 
      University, Nanjing 210002, China.
FAU - Shen, Xubo
AU  - Shen X
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
FAU - Tian, Kunming
AU  - Tian K
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
FAU - Zhou, Yuanzhong
AU  - Zhou Y
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
AD  - Key Laboratory of Maternal & Child Health and Exposure Science, Guizhou Higher 
      Education Institutes, School of Public Health, Zunyi Medical University, Zunyi 
      563000, China.
LA  - eng
GR  - QKHHBZ[2020]3002/The Science & Technology Program of Guizhou Province/
GR  - QKHPTRC-GCC[2022]039-1/the Science & Technology Program of Guizhou Province/
GR  - QKHPTRC-CXTD[2022]014/the Science & Technology Program of Guizhou Province/
GR  - QKH-J[2022]YB612/the Nature Science Foundation of Guizhou Province/
PT  - Journal Article
DEP - 20231016
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC10610734
OTO - NOTNLM
OT  - BKMR
OT  - Zunyi birth cohort
OT  - liver function
OT  - polycyclic aromatic hydrocarbons
OT  - pregnant women
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/27 12:44
MHDA- 2023/10/27 12:45
PMCR- 2023/10/16
CRDT- 2023/10/27 07:23
PHST- 2023/09/05 00:00 [received]
PHST- 2023/10/09 00:00 [revised]
PHST- 2023/10/12 00:00 [accepted]
PHST- 2023/10/27 12:45 [medline]
PHST- 2023/10/27 12:44 [pubmed]
PHST- 2023/10/27 07:23 [entrez]
PHST- 2023/10/16 00:00 [pmc-release]
AID - toxics11100863 [pii]
AID - toxics-11-00863 [pii]
AID - 10.3390/toxics11100863 [doi]
PST - epublish
SO  - Toxics. 2023 Oct 16;11(10):863. doi: 10.3390/toxics11100863.