PMID- 37888754
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231113
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 52
IP  - 6
DP  - 2023 Dec
TI  - Role of dendritic cell‑derived exosomes in allergic rhinitis (Review).
LID - 117 [pii]
LID - 10.3892/ijmm.2023.5320 [doi]
AB  - Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. 
      Its prevalence has been increasing worldwide and is becoming a major burden to 
      the world population. Dendritic cells (DCs) are typically activated and matured 
      after capturing, phagocytosing, and processing allergens during the 
      immunopathogenesis of AR. In addition, the process of DC activation and 
      maturation is accompanied by the production of exosomes, which are cell‑derived 
      extracellular vesicles (EVs) that can carry proteins, lipids, nucleic acids, and 
      other cargoes involved in intercellular communication and material transfer. In 
      particular, DC‑derived exosomes (Dex) can participate in allergic immune 
      responses, where the biological substances carried by them can have potentially 
      important implications for both the pathogenesis and treatment of AR. Dex can 
      also be exploited to carry anti‑allergy agents to effectively treat AR. This 
      provides a novel method to explore the pathogenesis of and treatment strategies 
      for AR further. Therefore, the present review focuses on the origin, composition, 
      function, and biological characteristics of DCs, exosomes, and Dex, in addition 
      to the possible relationship between Dex and AR.
FAU - Kang, Chenglin
AU  - Kang C
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - He, Haipeng
AU  - He H
AD  - Department of Otolaryngology, Longgang ENT Hospital and Shenzhen Key Laboratory 
      of ENT, Institute of ENT Shenzhen, Shenzhen, Guangdong 518172, P.R. China.
FAU - Liu, Peng
AU  - Liu P
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Liu, Yue
AU  - Liu Y
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Li, Xiaomei
AU  - Li X
AD  - Department of Otolaryngology, Second People's Hospital of Gansu Province, 
      Lanzhou, Gansu 730000, P.R. China.
FAU - Zhang, Jin
AU  - Zhang J
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Ran, Hong
AU  - Ran H
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Zeng, Xianhai
AU  - Zeng X
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Zhao, Hailiang
AU  - Zhao H
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Liu, Jiangqi
AU  - Liu J
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
FAU - Qiu, Shuqi
AU  - Qiu S
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, Guangdong 519041, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231027
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Allergens)
SB  - IM
MH  - Humans
MH  - *Exosomes
MH  - *Rhinitis, Allergic/metabolism
MH  - Allergens
MH  - *Extracellular Vesicles
MH  - Dendritic Cells
PMC - PMC10635688
OTO - NOTNLM
OT  - allergic rhinitis
OT  - dendritic cells
OT  - exosomes
OT  - extracellular vesicles
OT  - intercellular communication
COIS- The authors declare that they have no competing interests.
EDAT- 2023/10/27 12:44
MHDA- 2023/10/30 06:47
PMCR- 2023/10/20
CRDT- 2023/10/27 07:25
PHST- 2023/08/03 00:00 [received]
PHST- 2023/10/11 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/27 12:44 [pubmed]
PHST- 2023/10/27 07:25 [entrez]
PHST- 2023/10/20 00:00 [pmc-release]
AID - 117 [pii]
AID - ijmm-52-06-05320 [pii]
AID - 10.3892/ijmm.2023.5320 [doi]
PST - ppublish
SO  - Int J Mol Med. 2023 Dec;52(6):117. doi: 10.3892/ijmm.2023.5320. Epub 2023 Oct 27.