PMID- 37888915
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240410
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 390
IP  - 1
DP  - 2024 Jan 4
TI  - Drug-Eluting Resorbable Scaffold versus Angioplasty for Infrapopliteal Artery 
      Disease.
PG  - 9-19
LID - 10.1056/NEJMoa2305637 [doi]
AB  - BACKGROUND: Among patients with chronic limb-threatening ischemia (CLTI) and 
      infrapopliteal artery disease, angioplasty has been associated with frequent 
      reintervention and adverse limb outcomes from restenosis. The effect of the use 
      of drug-eluting resorbable scaffolds on these outcomes remains unknown. METHODS: 
      In this multicenter, randomized, controlled trial, 261 patients with CLTI and 
      infrapopliteal artery disease were randomly assigned in a 2:1 ratio to receive 
      treatment with an everolimus-eluting resorbable scaffold or angioplasty. The 
      primary efficacy end point was freedom from the following events at 1 year: 
      amputation above the ankle of the target limb, occlusion of the target vessel, 
      clinically driven revascularization of the target lesion, and binary restenosis 
      of the target lesion. The primary safety end point was freedom from major adverse 
      limb events at 6 months and from perioperative death. RESULTS: The primary 
      efficacy end point was observed (i.e., no events occurred) in 135 of 173 patients 
      in the scaffold group and 48 of 88 patients in the angioplasty group 
      (Kaplan-Meier estimate, 74% vs. 44%; absolute difference, 30 percentage points; 
      95% confidence interval [CI], 15 to 46; one-sided P<0.001 for superiority). The 
      primary safety end point was observed in 165 of 170 patients in the scaffold 
      group and 90 of 90 patients in the angioplasty group (absolute difference, -3 
      percentage points; 95% CI, -6 to 0; one-sided P<0.001 for noninferiority). 
      Serious adverse events related to the index procedure occurred in 2% of the 
      patients in the scaffold group and 3% of those in the angioplasty group. 
      CONCLUSIONS: Among patients with CLTI due to infrapopliteal artery disease, the 
      use of an everolimus-eluting resorbable scaffold was superior to angioplasty with 
      respect to the primary efficacy end point. (Funded by Abbott; LIFE-BTK 
      ClinicalTrials.gov number, NCT04227899.).
CI  - Copyright (c) 2023 Massachusetts Medical Society.
FAU - Varcoe, Ramon L
AU  - Varcoe RL
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - DeRubertis, Brian G
AU  - DeRubertis BG
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Kolluri, Raghu
AU  - Kolluri R
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Krishnan, Prakash
AU  - Krishnan P
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Metzger, David C
AU  - Metzger DC
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Bonaca, Marc P
AU  - Bonaca MP
AUID- ORCID: 0000-0002-9860-3584
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Shishehbor, Mehdi H
AU  - Shishehbor MH
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Holden, Andrew H
AU  - Holden AH
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Bajakian, Danielle R
AU  - Bajakian DR
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Garcia, Lawrence A
AU  - Garcia LA
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Kum, Steven W C
AU  - Kum SWC
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Rundback, John
AU  - Rundback J
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Armstrong, Ehrin
AU  - Armstrong E
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Lee, Jen-Kuang
AU  - Lee JK
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Khatib, Yazan
AU  - Khatib Y
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Weinberg, Ido
AU  - Weinberg I
AUID- ORCID: 0000-0003-4633-5132
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Garcia-Garcia, Hector M
AU  - Garcia-Garcia HM
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Ruster, Karine
AU  - Ruster K
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Teraphongphom, Nutte T
AU  - Teraphongphom NT
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Zheng, Yan
AU  - Zheng Y
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Wang, Jin
AU  - Wang J
AUID- ORCID: 0000-0002-5627-6642
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Jones-McMeans, Jennifer M
AU  - Jones-McMeans JM
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
FAU - Parikh, Sahil A
AU  - Parikh SA
AUID- ORCID: 0000-0002-0551-5885
AD  - From the Prince of Wales Hospital and University of New South Wales, Randwick, 
      Australia (R.L.V.); New York Presbyterian-Weill Cornell Medical Center (B.G.D.), 
      Mount Sinai Hospital (P.K.), and Columbia University Irving Medical Center and 
      Columbia Vagelos College of Physicians and Surgeons (D.R.B., S.A.P.), New York, 
      and Catholic Health Services, St. Francis Hospital and Heart Center, Roslyn 
      (L.A.G.) - all in New York; Syntropic Core Lab and OhioHealth Heart and Vascular, 
      Columbus (R.K.), and University Hospitals Harrington Heart and Vascular 
      Institute, Cleveland (M.H.S.) - both in Ohio; Ballad Health, Kingsport, TN 
      (D.C.M.); CPC Clinical Research, Cardiovascular Division, University of Colorado 
      School of Medicine, Aurora (M.P.B.), and Advanced Heart and Vein Center, Denver 
      (E.A.) - both in Colorado; Auckland Hospital and Auckland University, Grafton, 
      Auckland, New Zealand (A.H.H.); the Department of Surgery, Changi General 
      Hospital, Singapore (S.W.C.K.); Advanced Interventional and Vascular Services, 
      Teaneck, NJ (J.R.); National Taiwan University Hospital, Taipei City, Taiwan 
      (J.-K.L.); First Coast Cardiovascular Institute, Jacksonville, FL (Y.K.); 
      VasCore, Boston (I.W.); MedStar Washington Hospital Center, Washington, DC 
      (H.M.G.-G.); and Abbott Vascular, Santa Clara, CA (K.R., N.T.T., Y.Z., J.W., 
      J.M.J.-M.).
CN  - LIFE-BTK Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT04227899
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20231025
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 9HW64Q8G6G (Everolimus)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - Nat Rev Cardiol. 2024 Jan;21(1):8. PMID: 37932422
CIN - N Engl J Med. 2024 Apr 4;390(13):1243. PMID: 38598584
CIN - N Engl J Med. 2024 Apr 4;390(13):1243-1244. PMID: 38598585
CIN - N Engl J Med. 2024 Apr 4;390(13):1244-1245. PMID: 38598586
MH  - Humans
MH  - Absorbable Implants
MH  - *Angioplasty/adverse effects/methods
MH  - Angioplasty, Balloon/adverse effects/methods
MH  - *Blood Vessel Prosthesis Implantation/methods
MH  - Chronic Disease
MH  - *Chronic Limb-Threatening Ischemia/etiology/surgery
MH  - *Drug-Eluting Stents
MH  - Everolimus/administration & dosage/adverse effects/therapeutic use
MH  - Immunosuppressive Agents/administration & dosage/adverse effects/therapeutic use
MH  - Ischemia/drug therapy/etiology/surgery
MH  - *Peripheral Arterial Disease/complications/drug therapy/surgery
MH  - *Popliteal Artery/surgery
MH  - Tissue Scaffolds
MH  - Treatment Outcome
FIR - Varcoe, Ramon L
IR  - Varcoe RL
FIR - Parikh, Sahil A
IR  - Parikh SA
FIR - DeRubertis, Brian G
IR  - DeRubertis BG
FIR - Bajakian, Danielle R
IR  - Bajakian DR
FIR - Holden, Andrew
IR  - Holden A
FIR - Armstrong, Ehrin J
IR  - Armstrong EJ
FIR - Bonaca, Marc
IR  - Bonaca M
FIR - Krishnan, Prakash
IR  - Krishnan P
FIR - Kum, Steven
IR  - Kum S
FIR - Metzger, D Christopher
IR  - Metzger DC
FIR - Garcia, Lawrence
IR  - Garcia L
FIR - Rundback, John
IR  - Rundback J
FIR - Shishehbor, Mehdi
IR  - Shishehbor M
FIR - Yu, Shawn
IR  - Yu S
FIR - Liu, Guangda
IR  - Liu G
FIR - Nie, Hong
IR  - Nie H
FIR - Li, Xiaolin
IR  - Li X
FIR - Ying, Celes
IR  - Ying C
FIR - Toth, Cynthia
IR  - Toth C
FIR - Halsrud, Kristin
IR  - Halsrud K
FIR - Otterbach, Kim
IR  - Otterbach K
FIR - Rodriguez, Orlando
IR  - Rodriguez O
EDAT- 2023/10/27 12:43
MHDA- 2024/01/04 11:44
CRDT- 2023/10/27 08:33
PHST- 2024/01/04 11:44 [medline]
PHST- 2023/10/27 12:43 [pubmed]
PHST- 2023/10/27 08:33 [entrez]
AID - 10.1056/NEJMoa2305637 [doi]
PST - ppublish
SO  - N Engl J Med. 2024 Jan 4;390(1):9-19. doi: 10.1056/NEJMoa2305637. Epub 2023 Oct 
      25.