PMID- 37889169 OWN - NLM STAT- MEDLINE DCOM- 20231205 LR - 20231205 IS - 1558-9137 (Electronic) IS - 1059-0889 (Linking) VI - 32 IP - 4 DP - 2023 Dec 4 TI - Development and Application of a Reference-Interval Approach to Tympanometric Norms Using U.S. Population Data for Ages 6-80+ Years. PG - 908-929 LID - 10.1044/2023_AJA-23-00092 [doi] AB - PURPOSE: United States national data for tympanometric measures from 16,614 ears included in the National Health and Nutrition Examination Survey for 2015-2016 and 2017-2020 were analyzed and described. METHOD: Analyses were primarily descriptive and relied on distribution-free medians and cumulative distribution functions (CDFs). Differences between CDFs were examined using Cohen's h effect size. Results are presented for the age range 6-80+ years. A reference interval (RI) approach was pursued in which the interval from the 2.5th to the 95th percentile for healthy ears was specified for peak-compensated static admittance (Y(tm)+), tympanometric peak pressure, tympanometric width, and equivalent acoustic ear-canal volume (V(ea)+). RESULTS: Separate RIs were required for 6- to 13-year-olds compared to those 14-80+ years of age for all four tympanometric measures. For both age groups, a separate RI was warranted for each sex for Y(tm)+ and V(ea)+. For those 14-80+ years of age, a separate RI was also needed for non-Hispanic Asians for Y(tm)+. When these RIs were applied to the full data set, about 5%-10% of ears were found to be either below the lower limit or above the upper limit of the RI. Those ears outside the RI limits had about 5 dB higher low-frequency hearing thresholds than those within RI limits. Both Y(tm)+ and V(ea)+ were found to depend on body size. CONCLUSION: RIs for tympanometric measures from individuals with healthy ears were established, and when applied to the general U.S. population 6-80+ years of age, 5%-10% of ears fell outside the RIs depending on the measure. FAU - Humes, Larry AU - Humes L AUID- ORCID: 0000-0002-9668-3744 AD - Department of Speech, Language and Hearing Sciences, Indiana University, Bloomington. LA - eng PT - Journal Article DEP - 20231027 PL - United States TA - Am J Audiol JT - American journal of audiology JID - 9114917 SB - IM MH - Humans MH - United States MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - Nutrition Surveys MH - *Acoustic Impedance Tests/methods MH - *Hearing MH - Reference Values MH - Acoustics EDAT- 2023/10/27 12:43 MHDA- 2023/12/05 12:42 CRDT- 2023/10/27 10:03 PHST- 2023/12/05 12:42 [medline] PHST- 2023/10/27 12:43 [pubmed] PHST- 2023/10/27 10:03 [entrez] AID - 10.1044/2023_AJA-23-00092 [doi] PST - ppublish SO - Am J Audiol. 2023 Dec 4;32(4):908-929. doi: 10.1044/2023_AJA-23-00092. Epub 2023 Oct 27.