PMID- 37890103
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231216
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 46
IP  - 11
DP  - 2023 Nov 1
TI  - The Relationship Between Alcohol Consumption, BMI, and Type 2 Diabetes: A 
      Systematic Review and Dose-Response Meta-analysis.
PG  - 2076-2083
LID - 10.2337/dc23-1015 [doi]
AB  - BACKGROUND: Moderate alcohol use may be associated with lower risk of type 2 
      diabetes mellitus (T2DM). Previous reviews have reached mixed conclusions. 
      PURPOSE: To quantify the dose-response relationship between alcohol consumption 
      and T2DM, accounting for differential effects by sex and BMI. DATA SOURCES: 
      Medline, Embase, Web of Science, and one secondary data source. STUDY SELECTION: 
      Cohort studies on the relationship between alcohol use and T2DM. DATA EXTRACTION: 
      Fifty-five studies, and one secondary data source, were included with a combined 
      sample size of 1,363,355 men and 1,290,628 women, with 89,983 and 57,974 
      individuals, respectively, diagnosed with T2DM. DATA SYNTHESIS: Multivariate 
      dose-response meta-analytic random-effect models were used. For women, a J-shaped 
      relationship was found with a maximum risk reduction of 31% (relative risk [RR] 
      0.69, 95% CI 0.64-0.74) at an intake of 16 g of pure alcohol per day compared 
      with lifetime abstainers. The protective association ceased above 49 g per day 
      (RR 0.82, 95% CI 0.68-0.99). For men, no statistically significant relationship 
      was identified. When results were stratified by BMI, the protective association 
      was only found in overweight and obese women. LIMITATIONS: Our analysis relied on 
      aggregate data. We included some articles that determined exposure and cases via 
      self-report, and the studies did not account for temporal variations in alcohol 
      use. CONCLUSIONS: The observed reduced risk seems to be specific to women in 
      general and women with a BMI >/=25 kg/m2. Our findings allow for a more precise 
      prediction of the sex-specific relationship between T2DM and alcohol use, as our 
      results differ from those of previous studies.
CI  - (c) 2023 by the American Diabetes Association.
FAU - Llamosas-Falcon, Laura
AU  - Llamosas-Falcon L
AUID- ORCID: 0000-0003-4718-9376
AD  - Institute for Mental Health Policy Research, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Rehm, Jurgen
AU  - Rehm J
AD  - Institute for Mental Health Policy Research, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, 
      Canada.
AD  - Institute of Clinical Psychology and Psychotherapy & Center of Clinical 
      Epidemiology and Longitudinal Studies (CELOS), Technische Universitat Dresden, 
      Dresden, Germany.
AD  - Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry 
      and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
FAU - Bright, Sophie
AU  - Bright S
AD  - School of Health and Related Research (ScHARR), Faculty of Medicine, Dentistry & 
      Health, University of Sheffield, Sheffield, U.K.
FAU - Buckley, Charlotte
AU  - Buckley C
AD  - Department of Automatic Control and Systems Engineering, University of Sheffield, 
      Sheffield, U.K.
FAU - Carr, Tessa
AU  - Carr T
AD  - Institute for Mental Health Policy Research, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Kilian, Carolin
AU  - Kilian C
AD  - Institute for Mental Health Policy Research, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
FAU - Lasserre, Aurelie M
AU  - Lasserre AM
AD  - Addiction Medicine, Department of Psychiatry, Lausanne University Hospital, 
      Lausanne, Switzerland.
FAU - Lemp, Julia M
AU  - Lemp JM
AD  - Heidelberg Institute of Global Health, Medical Faculty and University Hospital, 
      University of Heidelberg, Heidelberg, Germany.
FAU - Zhu, Yachen
AU  - Zhu Y
AD  - Alcohol Research Group, Public Health Institute, Emeryville, CA.
FAU - Probst, Charlotte
AU  - Probst C
AD  - Institute for Mental Health Policy Research, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 
      Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Heidelberg Institute of Global Health, Medical Faculty and University Hospital, 
      University of Heidelberg, Heidelberg, Germany.
LA  - eng
GR  - R01 AA028009/AA/NIAAA NIH HHS/United States
GR  - R01AA028009/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Risk Factors
MH  - Body Mass Index
MH  - Alcohol Drinking/adverse effects/epidemiology
MH  - Cohort Studies
PMC - PMC10620538
COIS- Duality of Interest. No potential conflicts of interest relevant to this article 
      were reported.
EDAT- 2023/10/27 18:42
MHDA- 2023/10/30 06:46
PMCR- 2024/11/01
CRDT- 2023/10/27 15:53
PHST- 2023/06/01 00:00 [received]
PHST- 2023/08/26 00:00 [accepted]
PHST- 2024/11/01 00:00 [pmc-release]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/10/27 18:42 [pubmed]
PHST- 2023/10/27 15:53 [entrez]
AID - 153773 [pii]
AID - 231015 [pii]
AID - 10.2337/dc23-1015 [doi]
PST - ppublish
SO  - Diabetes Care. 2023 Nov 1;46(11):2076-2083. doi: 10.2337/dc23-1015.