PMID- 37890596 OWN - NLM STAT- MEDLINE DCOM- 20240322 LR - 20240322 IS - 1097-6779 (Electronic) IS - 0016-5107 (Linking) VI - 99 IP - 4 DP - 2024 Apr TI - Composite score of physiomechanical esophageal function using functional lumen imaging probe panometry in eosinophilic esophagitis. PG - 499-510.e1 LID - S0016-5107(23)03025-0 [pii] LID - 10.1016/j.gie.2023.10.048 [doi] AB - BACKGROUND AND AIMS: The evaluation provided by functional lumen imaging probe (FLIP) panometry includes esophageal distensibility/compliance (mechanics) of the esophageal body and esophagogastric junction (EGJ) and esophageal motility (secondary peristalsis). We developed a composite score using these parameters to characterize physiomechanical function in patients with eosinophilic esophagitis (EoE). METHODS: Two hundred fifteen adult patients with EoE who completed FLIP panometry during sedated endoscopy with esophageal biopsy sampling were included. FLIP metrics of esophageal body Compliance, Contractile response, Distensibility plateau, and maximum EGJ Diameter (C2D2) were scored as 0 for normal versus 1 or 2 for increasing degree of abnormality. Scores were summed to calculate the composite C2D2 score. RESULTS: The C2D2 score had a significant positive correlation with mucosal eosinophil count (rho = .241) and total Endoscopic EoE Reference Score (rho = .467). Among 46 patients off treatment at the baseline evaluation, future proton pump inhibitor (PPI) responders (ie, achieved mucosal eosinophil count <15 per high-powered field after PPI treatment) had lower C2D2 scores than PPI nonresponders (median, 2 [interquartile range, 1-3] vs 4 [interquartile range, 2-6], respectively; P = .003). A regression model (that controlled for age, sex, and baseline eosinophil count) showed a C2D2 score