PMID- 37891255
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231031
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Oct 27
TI  - Serum 25-hydroxyvitamin D level is associated with short-term glycemic 
      variability metrics derived from continuous glucose monitoring in T2DM.
PG  - 18463
LID - 10.1038/s41598-023-45846-1 [doi]
LID - 18463
AB  - This study aims to investigate the association between 25-hydroxyvitamin D 
      (25OHD) and continuous glucose monitoring-assessed short-term glycemic 
      variability (GV) and HbA1c among patients with type 2 diabetes mellitus (T2DM). 
      We conducted a cross-sectional study recruiting 325 patients. The association 
      between 25OHD and GV metrics (mean amplitude of glycemic excursions [MAGE], 
      coefficient of variation [CV], standard deviation of sensor glucose [SD], and 
      TIR) and HbA1c were analyzed using multivariable linear and logistic regression 
      analyses. The 25OHD level and GV metrics showed significant differences among 
      HbA1c groups (P < 0.01). CV, MAGE, SD and HbA1c decreased, and TIR increased with 
      ascending 25OHD tertiles (P < 0.05). Serum 25OHD was inversely associated with CV 
      (beta = - 0.211 [- 0.350 to - 0.071], P < 0.01) and HbA1c (beta = - 0.061 [- 0.114 to 
      - 0.031], P < 0.01), and further multivariable analyses confirmed these results 
      (P < 0.05). However, no association of HbA1c and 25OHD was found with the highest 
      tertile of CV. These findings revealed that increased GV and HbA1c were both 
      associated with lower 25OHD, and the relationship between HbA1c and 25OHD was 
      attenuated with higher glucose CV in T2DM. Taken together, the analyses suggest 
      that increasing vitamin D status has effects on improvements in long-term 
      glycemic control and low glycemic variability.
CI  - (c) 2023. The Author(s).
FAU - Zhao, Guohong
AU  - Zhao G
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Yu, Xinwen
AU  - Yu X
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Wang, Lin
AU  - Wang L
AD  - College of Medicine, Xi'an International University, Xi'an, 710077, Shaanxi 
      Province, People's Republic of China.
AD  - Engineering Research Center of Personalized Anti-Aging Health Product Development 
      and Transformation, Universities of Shaanxi Province, Xi'an, 710077, Shaanxi 
      Province, People's Republic of China.
FAU - Jin, Yuxin
AU  - Jin Y
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Yang, Aili
AU  - Yang A
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Sun, Fei
AU  - Sun F
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Jing, Xiaorui
AU  - Jing X
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China.
FAU - Gao, Bin
AU  - Gao B
AD  - Department of Endocrinology, Tangdu Hospital, Air Force Medical University, 
      Xi'an, 710038, Shaanxi Province, People's Republic of China. bingao0726@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231027
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin)
RN  - 1406-16-2 (Vitamin D)
RN  - P6YZ13C99Q (Calcifediol)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Blood Glucose/analysis
MH  - Glycated Hemoglobin
MH  - Blood Glucose Self-Monitoring
MH  - Cross-Sectional Studies
MH  - Vitamin D
MH  - Calcifediol
MH  - Glucose
PMC - PMC10611772
COIS- The authors declare no competing interests.
EDAT- 2023/10/28 11:42
MHDA- 2023/10/30 06:47
PMCR- 2023/10/27
CRDT- 2023/10/27 23:28
PHST- 2023/07/19 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/28 11:42 [pubmed]
PHST- 2023/10/27 23:28 [entrez]
PHST- 2023/10/27 00:00 [pmc-release]
AID - 10.1038/s41598-023-45846-1 [pii]
AID - 45846 [pii]
AID - 10.1038/s41598-023-45846-1 [doi]
PST - epublish
SO  - Sci Rep. 2023 Oct 27;13(1):18463. doi: 10.1038/s41598-023-45846-1.