PMID- 37891844
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 13
IP  - 10
DP  - 2023 Oct 19
TI  - Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of 
      Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant 
      Adverse Prognostic Factor.
LID - 10.3390/brainsci13101477 [doi]
LID - 1477
AB  - Malignant glioma is a highly invasive tumor, and elucidating the glioma invasion 
      mechanism is essential for developing novel therapies. We aimed to highlight 
      actin alpha 2, smooth muscle (ACTA2) as potential biomarkers of brain invasion 
      and distant recurrence in malignant gliomas. Using the human malignant glioma 
      cell line, U251MG, we generated ACTA2 knockdown (KD) cells treated with small 
      interfering RNA, and the cell motility and proliferation of the ACTA2 KD group 
      were analyzed. Furthermore, tumor samples from 12 glioma patients who underwent 
      reoperation at the time of tumor recurrence were utilized to measure ACTA2 
      expression in the tumors before and after recurrence. Thereafter, we examined how 
      ACTA2 expression correlates with the time to tumor recurrence and the mode of 
      recurrence. The results showed that the ACTA2 KD group demonstrated a decline in 
      the mean motion distance and proliferative capacity compared to the control 
      group. In the clinical glioma samples, ACTA2 expression was remarkably increased 
      in recurrent samples compared to the primary samples from the same patients, and 
      the higher the change in ACTCA2 expression from the start to relapse, the shorter 
      the progression-free survival. In conclusion, ACTA2 may be involved in distant 
      recurrence in clinical gliomas.
FAU - Hoshimaru, Takumi
AU  - Hoshimaru T
AUID- ORCID: 0009-0006-6264-1104
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Nonoguchi, Naosuke
AU  - Nonoguchi N
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kosaka, Takuya
AU  - Kosaka T
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Furuse, Motomasa
AU  - Furuse M
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kawabata, Shinji
AU  - Kawabata S
AUID- ORCID: 0000-0001-5007-5279
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Yagi, Ryokichi
AU  - Yagi R
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kurisu, Yoshitaka
AU  - Kurisu Y
AUID- ORCID: 0009-0002-3955-701X
AD  - Department of Pathology, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kashiwagi, Hideki
AU  - Kashiwagi H
AUID- ORCID: 0000-0003-3192-4065
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kameda, Masahiro
AU  - Kameda M
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Takami, Toshihiro
AU  - Takami T
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Kataoka-Sasaki, Yuko
AU  - Kataoka-Sasaki Y
AD  - Department of Neural Regenerative Medicine, Research Institute for Frontier 
      Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, 
      Japan.
FAU - Sasaki, Masanori
AU  - Sasaki M
AUID- ORCID: 0000-0001-7961-9698
AD  - Department of Neural Regenerative Medicine, Research Institute for Frontier 
      Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, 
      Japan.
FAU - Honmou, Osamu
AU  - Honmou O
AD  - Department of Neural Regenerative Medicine, Research Institute for Frontier 
      Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, 
      Japan.
FAU - Hiramatsu, Ryo
AU  - Hiramatsu R
AUID- ORCID: 0000-0002-5581-5472
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
FAU - Wanibuchi, Masahiko
AU  - Wanibuchi M
AUID- ORCID: 0000-0002-1856-7123
AD  - Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 
      569-8686, Japan.
LA  - eng
GR  - 20K09359/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20231019
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC10605410
OTO - NOTNLM
OT  - actin alpha
OT  - actin alpha 2
OT  - cardiac muscle 1 (ACTC1)
OT  - cell migration
OT  - cytoskeleton
OT  - high-grade glioma
OT  - recurrence
OT  - smooth muscle (ACTA2)
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:43
MHDA- 2023/10/28 11:44
PMCR- 2023/10/19
CRDT- 2023/10/28 01:00
PHST- 2023/09/27 00:00 [received]
PHST- 2023/10/17 00:00 [revised]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/10/28 11:44 [medline]
PHST- 2023/10/28 11:43 [pubmed]
PHST- 2023/10/28 01:00 [entrez]
PHST- 2023/10/19 00:00 [pmc-release]
AID - brainsci13101477 [pii]
AID - brainsci-13-01477 [pii]
AID - 10.3390/brainsci13101477 [doi]
PST - epublish
SO  - Brain Sci. 2023 Oct 19;13(10):1477. doi: 10.3390/brainsci13101477.