PMID- 37892217
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231030
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 10
DP  - 2023 Oct 17
TI  - Emerging Roles for Dendritic Cells in Heart Failure.
LID - 10.3390/biom13101535 [doi]
LID - 1535
AB  - The field of cardio-immunology has emerged from discoveries that define roles for 
      innate and adaptive immune responses associated with myocardial inflammation and 
      heart failure. Dendritic cells (DCs) comprise an important cellular compartment 
      that contributes to systemic immune surveillance at the junction of innate and 
      adaptive immunity. Once described as a singular immune subset, we now appreciate 
      that DCs consist of a heterogeneous pool of subpopulations, each with distinct 
      effector functions that can uniquely regulate the acute and chronic inflammatory 
      response. Nevertheless, the cardiovascular-specific context involving DCs in 
      negotiating the biological response to myocardial injury is not well understood. 
      Herein, we review our current understanding of the role of DCs in cardiac 
      inflammation and heart failure, including gaps in knowledge and clinical 
      relevance.
FAU - Saleh, Danish
AU  - Saleh D
AD  - Department of Medicine, Division of Cardiology, Feinberg School of Medicine, 
      Chicago, IL 60611, USA.
FAU - Jones, Rebecca T L
AU  - Jones RTL
AUID- ORCID: 0000-0002-0970-1968
AD  - Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
FAU - Schroth, Samantha L
AU  - Schroth SL
AD  - Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
FAU - Thorp, Edward B
AU  - Thorp EB
AD  - Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
AD  - Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
FAU - Feinstein, Matthew J
AU  - Feinstein MJ
AD  - Department of Medicine, Division of Cardiology, Feinberg School of Medicine, 
      Chicago, IL 60611, USA.
AD  - Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20231017
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
SB  - IM
MH  - Humans
MH  - *Heart Failure
MH  - *Myocarditis
MH  - Inflammation
MH  - Adaptive Immunity
MH  - Dendritic Cells
PMC - PMC10605025
OTO - NOTNLM
OT  - T cells
OT  - cardio-immunology
OT  - dendritic cells
OT  - dilated cardiomyopathy
OT  - heart failure
OT  - heart-failure with preserved ejection fraction (HFpEF)
OT  - hypertensive heart disease
OT  - ischemic cardiomyopathy
OT  - myocardial inflammation
OT  - myocarditis
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:46
MHDA- 2023/10/30 06:46
PMCR- 2023/10/17
CRDT- 2023/10/28 01:03
PHST- 2023/09/19 00:00 [received]
PHST- 2023/10/10 00:00 [revised]
PHST- 2023/10/13 00:00 [accepted]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/10/28 11:46 [pubmed]
PHST- 2023/10/28 01:03 [entrez]
PHST- 2023/10/17 00:00 [pmc-release]
AID - biom13101535 [pii]
AID - biomolecules-13-01535 [pii]
AID - 10.3390/biom13101535 [doi]
PST - epublish
SO  - Biomolecules. 2023 Oct 17;13(10):1535. doi: 10.3390/biom13101535.