PMID- 37892261
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 10
IP  - 10
DP  - 2023 Sep 25
TI  - Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post COVID-19 
      Condition in Children and Adolescents.
LID - 10.3390/children10101598 [doi]
LID - 1598
AB  - SARS-CoV-2 infection causes transient cardiorespiratory and neurological 
      disorders, and severe acute illness is rare among children. Post COVID-19 
      condition (PCC) may cause profound, persistent phenotypes with increasing 
      prevalence. Its manifestation and risk factors remain elusive. In this 
      monocentric study, we hypothesized that atopy, the tendency to produce an 
      exaggerated immunoglobulin E (IgE) immune response, is a risk factor for the 
      manifestation of pediatric PCC. We present a patient cohort (n = 28) from an 
      early pandemic period (2021-2022) with comprehensive evaluations of phenotypes, 
      pulmonary function, and molecular investigations. PCC predominantly affected 
      adolescents and presented with fatigue, dyspnea, and post-exertional malaise. 
      Sensitizations to aeroallergens were found in 93% of cases. We observed elevated 
      IgE levels (mean 174.2 kU/L, reference < 100 kU/L) regardless of disease 
      severity. Concurrent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) 
      was found in 29% of patients that also faced challenges in school attendance. 
      ME/CFS manifestation was significantly associated with elevated immunoglobulin G 
      subclasses IgG3 (p < 0.05) and IgG4 (p < 0.05). A total of 57% of patients showed 
      self-limiting disease courses with mean recovery at 12.7 months (range 5-25 
      months), 29% at 19.2 months (range 12-30 months), and the rest demonstrated 
      overall improvement. These findings offer additional insights into immune 
      dysregulation as a risk factor for pediatric PCC.
FAU - Korner, Robert Walter
AU  - Korner RW
AUID- ORCID: 0000-0003-3164-4952
AD  - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
FAU - Bansemir, Ole Yannick
AU  - Bansemir OY
AD  - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
FAU - Franke, Rosa
AU  - Franke R
AD  - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
FAU - Sturm, Julius
AU  - Sturm J
AD  - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
FAU - Dafsari, Hormos Salimi
AU  - Dafsari HS
AD  - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
AD  - Center for Rare Diseases, Faculty of Medicine and University Hospital Cologne, 
      University of Cologne, 50937 Cologne, Germany.
AD  - Max-Planck-Institute for Biology of Ageing, 50931 Cologne, Germany.
AD  - Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated 
      Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
LA  - eng
GR  - 413543196/Cologne Clinician Scientist Program / Medical Faculty / University of 
      Cologne and German Research Foundation/
PT  - Journal Article
DEP - 20230925
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10605545
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - adolescents
OT  - atopic disease
OT  - children
OT  - long COVID
OT  - post COVID-19 condition
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/10/28 11:44
MHDA- 2023/10/28 11:45
PMCR- 2023/09/25
CRDT- 2023/10/28 01:03
PHST- 2023/08/20 00:00 [received]
PHST- 2023/09/04 00:00 [revised]
PHST- 2023/09/12 00:00 [accepted]
PHST- 2023/10/28 11:45 [medline]
PHST- 2023/10/28 11:44 [pubmed]
PHST- 2023/10/28 01:03 [entrez]
PHST- 2023/09/25 00:00 [pmc-release]
AID - children10101598 [pii]
AID - children-10-01598 [pii]
AID - 10.3390/children10101598 [doi]
PST - epublish
SO  - Children (Basel). 2023 Sep 25;10(10):1598. doi: 10.3390/children10101598.