PMID- 37892809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 20
DP  - 2023 Oct 22
TI  - The Correlation between Retinal and Choroidal Thickness with Age-Related White 
      Matter Hyperintensities in Progressive Supranuclear Palsy.
LID - 10.3390/jcm12206671 [doi]
LID - 6671
AB  - Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. 
      Recently, several retinal layers in PSP compared to healthy controls. were found 
      to be thinner. However, no studies evaluating the correlation between retinal 
      layers and cerebral white matter changes, nor eventual choroidal changes in PSP, 
      have been conducted so far. The goals of the present study were to explore 
      potential differences in choroidal structure between PSP and healthy controls, 
      and to describe the relationship between retinal layers' thickness and volume, 
      using spectral-domain optical coherence tomography (SD-OCT) and age-related white 
      matter change scores (ARWMC) using magnetic resonance imaging (MRI) of the brain. 
      Choroidal structures of 26 PSP patients and 26 healthy controls using standard 
      SD-OCT with an enhanced depth imaging (EDI) approach were analyzed; then, retinal 
      the structures of 16 of these PSP patients using standard SD-OCT were examined; 
      finally, the same patients underwent brain MRI, and their cerebral white matter 
      changes were calculated. Non-statistically significant differences between PSP 
      patients' and healthy controls' choroidal structure were found. On the contrary, 
      PSP patients' inner retinal layers (INR), retinal pigmented epithelium (RPE) and 
      all retinal layers' thicknesses in the macular region were found to be 
      significantly correlated with ARWMC, independently from age and axial length 
      (AL). PSP patients' neurological alterations go hand in hand with retinal ones, 
      independently from age and axial length. Our results suggest a mutual 
      relationship between cerebral and retinal structure pathological alterations. On 
      the other hand, no significant differences in the choroidal evaluation compared 
      to healthy controls have been found.
FAU - De Bernardo, Maddalena
AU  - De Bernardo M
AUID- ORCID: 0000-0003-4566-0064
AD  - Eye Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica 
      Salernitana", University of Salerno, 84084 Fisciano, Italy.
FAU - Diana, Francesco
AU  - Diana F
AUID- ORCID: 0000-0002-3245-917X
AD  - Neuroradiology Unit, University Hospital San Giovanni di Dio e Ruggi d'Aragona, 
      84131 Salerno, Italy.
AD  - Interventional Neurology Department, Vall d'Hebron University Hospital, 08035 
      Barcelona, Spain.
FAU - Gioia, Marco
AU  - Gioia M
AUID- ORCID: 0000-0002-4474-3020
AD  - Eye Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica 
      Salernitana", University of Salerno, 84084 Fisciano, Italy.
FAU - De Luca, Martina
AU  - De Luca M
AUID- ORCID: 0000-0002-8825-4675
AD  - Eye Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica 
      Salernitana", University of Salerno, 84084 Fisciano, Italy.
FAU - Tepedino, Maria Francesca
AU  - Tepedino MF
AD  - Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery 
      and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, 
      Italy.
FAU - Pellecchia, Maria Teresa
AU  - Pellecchia MT
AD  - Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery 
      and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, 
      Italy.
FAU - Rosa, Nicola
AU  - Rosa N
AUID- ORCID: 0000-0002-2366-6556
AD  - Eye Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica 
      Salernitana", University of Salerno, 84084 Fisciano, Italy.
FAU - Barone, Paolo
AU  - Barone P
AD  - Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery 
      and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, 
      Italy.
FAU - Picillo, Marina
AU  - Picillo M
AD  - Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery 
      and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20231022
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10607459
OTO - NOTNLM
OT  - choroid
OT  - neuroradiology
OT  - optical coherence tomography
OT  - progressive supranuclear palsy
OT  - retina
OT  - white matter age-related changes
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:42
MHDA- 2023/10/28 11:43
PMCR- 2023/10/22
CRDT- 2023/10/28 01:06
PHST- 2023/09/23 00:00 [received]
PHST- 2023/10/11 00:00 [revised]
PHST- 2023/10/19 00:00 [accepted]
PHST- 2023/10/28 11:43 [medline]
PHST- 2023/10/28 11:42 [pubmed]
PHST- 2023/10/28 01:06 [entrez]
PHST- 2023/10/22 00:00 [pmc-release]
AID - jcm12206671 [pii]
AID - jcm-12-06671 [pii]
AID - 10.3390/jcm12206671 [doi]
PST - epublish
SO  - J Clin Med. 2023 Oct 22;12(20):6671. doi: 10.3390/jcm12206671.