PMID- 37894464
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 20
DP  - 2023 Oct 22
TI  - Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review.
LID - 10.3390/cancers15205096 [doi]
LID - 5096
AB  - Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among 
      head and neck cancers. Despite a lower incidence of laryngeal carcinoma, new 
      diagnostic techniques, and more targeted therapies, the overall survival has not 
      changed significantly in the last decades, leading to a negative prognosis in 
      advanced stages. Recently, several studies have focused on the identification of 
      biomarkers that may play a critical role in the pathogenesis of LSCC. Reviewing 
      the literature on the main databases, this study aims to investigate the role of 
      some biomarkers in LSCC that are correlated with oxidative stress and 
      inflammation: heat shock proteins; metallothioneins; nuclear factor erythroid 
      2-related factor 2; heme oxygenase; cyclooxygenase-2; and micro ribonucleic 
      acids. This review shows that biomarker expression depends on the type, grade of 
      differentiation, stage, and site of carcinoma. In addition, the role of these 
      biomarkers in LSCC is still little-known and little-studied. However, the study 
      of biomarker expression and the detection of a possible correlation with 
      patients' epidemiological, clinicopathological, and therapeutics data may lead to 
      better awareness and knowledge of the tumor, to the identification of the best 
      therapeutic strategy, and the most proper follow-up protocol tailored for each 
      patient. In conclusion, the achievement of these goals may improve the prognosis 
      of LSCC patients.
FAU - Verro, Barbara
AU  - Verro B
AUID- ORCID: 0000-0002-1940-5281
AD  - Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and 
      Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy.
FAU - Saraniti, Carmelo
AU  - Saraniti C
AUID- ORCID: 0000-0002-1072-0736
AD  - Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and 
      Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy.
FAU - Carlisi, Daniela
AU  - Carlisi D
AUID- ORCID: 0000-0002-5833-7904
AD  - Section of Biochemistry, Department of Biomedicine, Neuroscience and Advanced 
      Diagnostic, University of Palermo, 90127 Palermo, Italy.
FAU - Chiesa-Estomba, Carlos
AU  - Chiesa-Estomba C
AD  - Head and Neck Surgery Research Group of Young Otolaryngologists of International 
      Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France.
AD  - Otorhinolaryngology-Head & Neck Surgery Department, Donostia University Hospital, 
      Biodonostia Research Institute, Faculty of Medicine, Deusto University, 20014 
      Donostia, Spain.
FAU - Maniaci, Antonino
AU  - Maniaci A
AD  - Head and Neck Surgery Research Group of Young Otolaryngologists of International 
      Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France.
AD  - Faculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
FAU - Lechien, Jerome R
AU  - Lechien JR
AUID- ORCID: 0000-0002-0845-0845
AD  - Head and Neck Surgery Research Group of Young Otolaryngologists of International 
      Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France.
AD  - Division of Laryngology and Bronchoesophagology, Department of 
      Otolaryngology-Head and Neck Surgery, Epicura Hospital, University of Mons, B7000 
      Mons, Belgium.
FAU - Mayo, Miguel
AU  - Mayo M
AUID- ORCID: 0000-0002-1829-6597
AD  - Head and Neck Surgery Research Group of Young Otolaryngologists of International 
      Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Complexo Hospitalario 
      Universitario A Coruna (CHUAC), 15006 A Coruna, Spain.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Hospital San Rafael 
      (HSR), 15006 A Coruna, Spain.
FAU - Fakhry, Nicolas
AU  - Fakhry N
AD  - Head and Neck Surgery Research Group of Young Otolaryngologists of International 
      Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France.
AD  - Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception 
      University Hospital, Assistance Publique-Hopitaux de Marseille, Aix Marseille 
      University, 13005 Marseille, France.
FAU - Lauricella, Marianna
AU  - Lauricella M
AUID- ORCID: 0000-0002-0157-3834
AD  - Section of Biochemistry, Department of Biomedicine, Neuroscience and Advanced 
      Diagnostic, University of Palermo, 90127 Palermo, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231022
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10604942
OTO - NOTNLM
OT  - biomarkers
OT  - cyclooxygenase-2
OT  - heat shock proteins
OT  - heme oxygenase
OT  - laryngeal cancer
OT  - larynx
OT  - metallothioneins
OT  - micro ribonucleic acid
OT  - nuclear factor erythroid 2-related factor 2
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:47
MHDA- 2023/10/28 11:48
PMCR- 2023/10/22
CRDT- 2023/10/28 01:15
PHST- 2023/09/14 00:00 [received]
PHST- 2023/10/13 00:00 [revised]
PHST- 2023/10/20 00:00 [accepted]
PHST- 2023/10/28 11:48 [medline]
PHST- 2023/10/28 11:47 [pubmed]
PHST- 2023/10/28 01:15 [entrez]
PHST- 2023/10/22 00:00 [pmc-release]
AID - cancers15205096 [pii]
AID - cancers-15-05096 [pii]
AID - 10.3390/cancers15205096 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Oct 22;15(20):5096. doi: 10.3390/cancers15205096.