PMID- 37895076
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231030
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 20
DP  - 2023 Oct 20
TI  - Association of HLA-A*11:01, -A*24:02, and -B*18:01 with Prostate Cancer Risk: A 
      Case-Control Study.
LID - 10.3390/ijms242015398 [doi]
LID - 15398
AB  - The major histocompatibility complex (MHC) loci, the most polymorphic regions 
      within the human genome, encode protein complexes responsible for antigen 
      presentation and CD4+ and CD8+ cell activation. In prostate cancer (PCa), the 
      second most diagnosed cancer in the male population, MHC loci undergo significant 
      changes in their expression patterns, which affect the ability of the immune 
      system to attack and eliminate malignant cells. The purpose of this study was to 
      explore the genetic diversity of human leukocyte antigen (HLA)-A and HLA-B in 
      patients with PCa and healthy controls (HCs) by performing HLA genotyping using 
      NGS technology. The analysis highlighted statistically significant differences (p 
      < 0.05) in the prevalence of three alleles (A*11:01, A*24:02, and B*18:01). Among 
      the HCs analyzed, 14.89% had A*11:01, 20.21% had A*24:02, and 30.61% had B*18:01; 
      while 5.21% of patients with PCa presented A*11:01, 9.38% presented A*24:02, 
      18.08% presented B*18:01. Odds ratio (OR) calculations underlined a negative 
      association between the three alleles and the risk of PCa (OR < 1). The results 
      presented in this study suggest a protective role of A*11:01, A*24:02, and 
      B*18:01 in PCa.
FAU - Manca, Maria Antonietta
AU  - Manca MA
AD  - Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 Sassari, Italy.
FAU - Simula, Elena Rita
AU  - Simula ER
AUID- ORCID: 0000-0002-8946-2679
AD  - Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 Sassari, Italy.
FAU - Cossu, Davide
AU  - Cossu D
AUID- ORCID: 0000-0002-0557-9467
AD  - Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 Sassari, Italy.
FAU - Solinas, Tatiana
AU  - Solinas T
AD  - Dipartimento di Medicina, Chirurgia e Farmacia, Universita di Sassari, 07100 
      Sassari, Italy.
AD  - Struttura Complessa di Urologia, Azienda Ospedaliera Universitaria, 07100 
      Sassari, Italy.
FAU - Madonia, Massimo
AU  - Madonia M
AD  - Dipartimento di Medicina, Chirurgia e Farmacia, Universita di Sassari, 07100 
      Sassari, Italy.
AD  - Struttura Complessa di Urologia, Azienda Ospedaliera Universitaria, 07100 
      Sassari, Italy.
FAU - Cusano, Roberto
AU  - Cusano R
AD  - CRS4, Pula, 09100 Cagliari, Italy.
FAU - Sechi, Leonardo Antonio
AU  - Sechi LA
AUID- ORCID: 0000-0003-0566-2049
AD  - Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 Sassari, Italy.
AD  - Struttura Complessa di Microbiologia e Virologia, Azienda Ospedaliera 
      Universitaria, 07100 Sassari, Italy.
LA  - eng
GR  - n: 2022BP837R to LAS/MUR, PRIN 2022/
GR  - legge regionale 12 22 Dicembre 2022 n. 22 to LAS/Regione Autonoma della Sardegna/
PT  - Journal Article
DEP - 20231020
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens)
SB  - IM
MH  - Humans
MH  - Male
MH  - Case-Control Studies
MH  - *HLA-A Antigens
MH  - HLA-B Antigens
MH  - Major Histocompatibility Complex
MH  - Histocompatibility Antigens
MH  - Alleles
MH  - Haplotypes
MH  - *Neoplasms/genetics
PMC - PMC10607162
OTO - NOTNLM
OT  - HLA-A*11:01
OT  - HLA-A*24:02
OT  - HLA-B*18:01
OT  - prostate cancer
COIS- The authors declared no conflict of interest.
EDAT- 2023/10/28 11:42
MHDA- 2023/10/30 06:47
PMCR- 2023/10/20
CRDT- 2023/10/28 01:19
PHST- 2023/08/29 00:00 [received]
PHST- 2023/10/09 00:00 [revised]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/28 11:42 [pubmed]
PHST- 2023/10/28 01:19 [entrez]
PHST- 2023/10/20 00:00 [pmc-release]
AID - ijms242015398 [pii]
AID - ijms-24-15398 [pii]
AID - 10.3390/ijms242015398 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Oct 20;24(20):15398. doi: 10.3390/ijms242015398.