PMID- 37895105
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231030
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 20
DP  - 2023 Oct 21
TI  - Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and 
      Animal Behavior.
LID - 10.3390/ijms242015415 [doi]
LID - 15415
AB  - The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), 
      has been believed to adjust the formation of an excitatory synapse. The positive 
      regulation of TRPC6 engenders synapse enlargement and improved learning and 
      memory in animal models. TRPC6 is involved in different synaptoprotective 
      signaling pathways, including antagonism of N-methyl-D-aspartate receptor 
      (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic 
      store-operated calcium entry. Positive regulation of TRPC6 channels has been 
      repeatedly shown to be good for memory formation and storage. TRPC6 is mainly 
      expressed in the hippocampus, particularly in the dentate granule cells, cornu 
      Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic 
      interneurons. It has been observed that TRPC6 agonists have a great influence on 
      animal behavior including memory formation and storage The purpose of this review 
      is to collect the available information on the role of TRPC6 in memory formation 
      in various parts of the brain to understand how TRPC6-specific pharmaceutical 
      agents will affect memory in distinct parts of the central nervous system (CNS).
FAU - Zernov, Nikita
AU  - Zernov N
AUID- ORCID: 0000-0002-4068-3032
AD  - Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg 
      Polytechnic University, 195251 St. Petersburg, Russia.
FAU - Popugaeva, Elena
AU  - Popugaeva E
AUID- ORCID: 0000-0002-6649-0802
AD  - Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg 
      Polytechnic University, 195251 St. Petersburg, Russia.
LA  - eng
GR  - 20-75-10026/Russian Science Foundation/
PT  - Journal Article
PT  - Review
DEP - 20231021
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (TRPC6 Cation Channel)
RN  - 0 (TRPC Cation Channels)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - TRPC6 Cation Channel
MH  - *TRPC Cation Channels/metabolism
MH  - *Neurons/metabolism
MH  - Synapses/metabolism
MH  - Behavior, Animal
MH  - Calcium/metabolism
PMC - PMC10607207
OTO - NOTNLM
OT  - TRPC6
OT  - behavior
OT  - memory
OT  - neuroprotection
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:46
MHDA- 2023/10/30 06:46
PMCR- 2023/10/21
CRDT- 2023/10/28 01:19
PHST- 2023/09/08 00:00 [received]
PHST- 2023/10/11 00:00 [revised]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/10/28 11:46 [pubmed]
PHST- 2023/10/28 01:19 [entrez]
PHST- 2023/10/21 00:00 [pmc-release]
AID - ijms242015415 [pii]
AID - ijms-24-15415 [pii]
AID - 10.3390/ijms242015415 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Oct 21;24(20):15415. doi: 10.3390/ijms242015415.