PMID- 37895973
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 16
IP  - 10
DP  - 2023 Oct 23
TI  - Self-Assembling Polymers with p-Aminosalicylate Anions Supported by Encapsulation 
      of p-Aminosalicylate for the Improvement of Drug Content and Release Efficiency.
LID - 10.3390/ph16101502 [doi]
LID - 1502
AB  - Bioactive linear choline-based copolymers were developed as micellar carriers for 
      drug delivery systems (DDSs). The polymethacrylates containing trimethylammonium 
      groups with p-aminosalicylate anions (PAS-based copolymers: series 1) or chloride 
      anions (Cl-based copolymers: series 2) differing in ionic content and chain 
      length were selected for drug loading. The diverse structures of amphiphilic 
      copolymers made it possible to adjust the encapsulation efficiency of a 
      well-known antibiotic, i.e., p-aminosalicylate in the form of sodium salt (PASNa) 
      or acid (PASA), providing single drug systems. Goniometry was applied to verify 
      the self-assembly capacity of the copolymers using the critical micelle 
      concentration (CMC = 0.03-0.18 mg/mL) and the hydrophilicity level quantifying 
      the surface wettability of polymer film using the water contact angle (WCA = 
      30-53 degrees ). Both parameters were regulated by the copolymer composition, indicating 
      that the increase in ionic content caused higher CMC and lower WCA, but the 
      latter was also modified to a less hydrophilic surface by drug encapsulation. The 
      drug content (DC) in the PAS-based polymers was increased twice by encapsulation 
      of PASNa and PASA (47-96% and 86-104%), whereas in the chloride-based polymer 
      systems, the drug was loaded in 43-96% and 73-100%, respectively. Efficient drug 
      release was detected for PASNa (80-100% series 1; 50-100% series 2) and PASA as 
      complete in both series. The strategy of loading extra drug by encapsulation, 
      which enhances the drug content in the copolymers containing anions of the same 
      pharmaceutics, provided promising characteristics, which highlight the potential 
      of PAS-loaded micellar copolymers for drug delivery.
FAU - Keihankhadiv, Shadi
AU  - Keihankhadiv S
AUID- ORCID: 0000-0002-1179-6724
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
FAU - Neugebauer, Dorota
AU  - Neugebauer D
AUID- ORCID: 0000-0002-3802-744X
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
LA  - eng
GR  - BKM-546/RCH4/2023 (04/040/BKM23/0260)/Grant for Young Scientists/
PT  - Journal Article
DEP - 20231023
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC10610373
OTO - NOTNLM
OT  - anti-tuberculosis
OT  - choline
OT  - drug delivery system
OT  - poly(ionic liquid)
OT  - polymeric carrier
OT  - self-assembly
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/28 11:46
MHDA- 2023/10/28 11:47
PMCR- 2023/10/23
CRDT- 2023/10/28 01:24
PHST- 2023/09/12 00:00 [received]
PHST- 2023/10/13 00:00 [revised]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/10/28 11:47 [medline]
PHST- 2023/10/28 11:46 [pubmed]
PHST- 2023/10/28 01:24 [entrez]
PHST- 2023/10/23 00:00 [pmc-release]
AID - ph16101502 [pii]
AID - pharmaceuticals-16-01502 [pii]
AID - 10.3390/ph16101502 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2023 Oct 23;16(10):1502. doi: 10.3390/ph16101502.