PMID- 37897203
OWN - NLM
STAT- MEDLINE
DCOM- 20240312
LR  - 20240312
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 47
IP  - 2
DP  - 2024 Mar
TI  - Pharmacokinetics of meloxicam in pre-ruminant calves after intravenous, oral, and 
      subcutaneous administration.
PG  - 143-149
LID - 10.1111/jvp.13412 [doi]
AB  - Meloxicam is routinely used for pain alleviation in pre-ruminant calves during 
      husbandry procedures. The pharmacokinetics of a single dose (0.5 mg/kg) of 
      meloxicam was investigated after intravenous (IV), subcutaneous (SC), and oral 
      (PO) administration in 30 pre-ruminant calves. Each group included 10 calves. 
      Oral meloxicam was administered at least 1 h after feeding. Plasma samples were 
      collected for up to 168 h, and the meloxicam concentration was analysed with 
      liquid chromatography and mass spectrometry, followed by a noncompartmental 
      pharmacokinetic analysis. The maximum meloxicam concentrations in plasma were 
      1.91 +/- 0.27 mug/mL and 1.77 +/- 0.16 mug/mL after SC and PO routes, respectively. The 
      time of maximum concentration was 7.6 +/- 2.8 h after SC and 10.0 +/- 5.7 h after PO 
      administration. The approximate bioavailability of meloxicam was 97% for SC and 
      PO routes. The elimination half-lives were 79.2 +/- 12.4, 84.6 +/- 24.8, and 
      84.8 +/- 22.3 h after IV, SC, and PO routes, respectively. The results suggest that 
      the therapeutic meloxicam concentrations in plasma that are required for pain 
      relief in other species, such as horses, may be maintained for several days 
      following a single dose (0.5 mg/kg) administered IV, SC, or PO in calves.
CI  - (c) 2023 The Authors. Journal of Veterinary Pharmacology and Therapeutics published 
      by John Wiley & Sons Ltd.
FAU - Jokela, Annemari
AU  - Jokela A
AUID- ORCID: 0009-0008-6517-7591
AD  - Department of Production Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Nyrhila, Alexandra
AU  - Nyrhila A
AD  - Department of Production Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Adam, Magdy
AU  - Adam M
AUID- ORCID: 0000-0002-2473-5912
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, 
      Beni-Suef, Egypt.
FAU - Salla, Kati
AU  - Salla K
AUID- ORCID: 0000-0003-4975-5060
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Raekallio, Marja
AU  - Raekallio M
AUID- ORCID: 0000-0002-2653-003X
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Aho, Riikka
AU  - Aho R
AUID- ORCID: 0009-0003-8143-2664
AD  - Department of Production Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Norring, Marianna
AU  - Norring M
AUID- ORCID: 0000-0001-8130-3959
AD  - Department of Production Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Hokkanen, Ann-Helena
AU  - Hokkanen AH
AUID- ORCID: 0000-0002-2011-4596
AD  - Department of Production Animal Medicine, Faculty of Veterinary Medicine, 
      University of Helsinki, Helsinki, Finland.
AD  - Research Centre for Animal Welfare, Faculty of Veterinary Medicine, University of 
      Helsinki, Helsinki, Finland.
LA  - eng
GR  - Finnish Foundation of Veterinary Research/
GR  - The Finnish Veterinary Foundation/
GR  - Juliana von Wendt Foundation/
GR  - Vetcare Finland Ltd./
GR  - Walter Ehrstrom Foundation/
PT  - Journal Article
DEP - 20231028
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - VG2QF83CGL (Meloxicam)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
SB  - IM
MH  - Cattle
MH  - Animals
MH  - Horses
MH  - Meloxicam/therapeutic use
MH  - *Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics
MH  - *Thiazines/pharmacokinetics
MH  - Thiazoles/pharmacokinetics
MH  - Half-Life
MH  - Area Under Curve
MH  - Pain/veterinary
MH  - Administration, Oral
MH  - Ruminants
OTO - NOTNLM
OT  - bioavailability
OT  - calf
OT  - meloxicam
OT  - pharmacokinetics
OT  - pre-ruminant
EDAT- 2023/10/28 11:45
MHDA- 2024/03/12 06:43
CRDT- 2023/10/28 04:33
PHST- 2023/09/05 00:00 [revised]
PHST- 2023/05/07 00:00 [received]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2024/03/12 06:43 [medline]
PHST- 2023/10/28 11:45 [pubmed]
PHST- 2023/10/28 04:33 [entrez]
AID - 10.1111/jvp.13412 [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2024 Mar;47(2):143-149. doi: 10.1111/jvp.13412. Epub 2023 
      Oct 28.