PMID- 37897219
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231113
IS  - 1532-4117 (Electronic)
IS  - 1093-4529 (Linking)
VI  - 58
IP  - 12
DP  - 2023
TI  - Influence of phthalate and non-phthalate plasticizers on reproductive endocrine 
      system-related gene expression profiles in Japanese medaka (Oryzias latipes).
PG  - 954-962
LID - 10.1080/10934529.2023.2273690 [doi]
AB  - Plasticizers containing phthalates have the potential to alter endocrine function 
      in vertebrates. While non-phthalate plasticizers were previously considered to be 
      environmentally friendly and safe, our research team discovered that 
      bis-(2-ethylhexyl) adipate (DEHA) and acetyl tributyl citrate (ATBC) disrupt 
      thyroid hormones in Japanese medaka (Oryzias latipes). We assessed reproductive- 
      and estrogen-responsive gene expression patterns in Japanese medaka to determine 
      whether the phthalate plasticizers bis-(2-ethylhexyl) phthalate (DEHP, positive 
      control) and the non-phthalate plasticizers DEHA and ATBC disrupt endocrine 
      signaling. The results showed that the levels of choriogenin H (chgH) and 
      vitellogenin (vtg) genes increased after exposure to DEHP and ATBC, suggesting 
      that these plasticizers may have estrogenic activity. Exposure to DEHP and DEHA 
      resulted in the upregulation of kisspeptin (kiss), gonadotropin-releasing hormone 
      (gnrh), and follicle-stimulating hormone beta (fshbeta) genes, suggesting that these 
      plasticizers may interfere with reproductive function. To the best of our 
      knowledge, this is the first study to demonstrate that the non-phthalate 
      plasticizers DEHA and ATBC can disrupt reproduction-related hormonal activity in 
      fish.
FAU - Horie, Yoshifumi
AU  - Horie Y
AD  - Research Center for Inland Seas (KURCIS), Kobe University, Kobe, Japan.
FAU - Uaciquete, Dorcas
AU  - Uaciquete D
AD  - Research Center for Inland Seas (KURCIS), Kobe University, Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231110
PL  - England
TA  - J Environ Sci Health A Tox Hazard Subst Environ Eng
JT  - Journal of environmental science and health. Part A, Toxic/hazardous substances & 
      environmental engineering
JID - 9812551
RN  - 0 (Plasticizers)
RN  - 6O7F7IX66E (phthalic acid)
RN  - 2BD76YG9SI (dioctyl adipate)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Animals
MH  - Plasticizers/toxicity
MH  - *Diethylhexyl Phthalate/toxicity
MH  - *Oryzias/genetics
MH  - Transcriptome
MH  - *Phthalic Acids/toxicity
MH  - Endocrine System
MH  - Reproduction
OTO - NOTNLM
OT  - ATBC
OT  - biomarker
OT  - dEHA
OT  - dEHP
OT  - ecotoxicity
OT  - endocrine disruption
OT  - fish toxicity
OT  - gene expression
OT  - plasticizers
EDAT- 2023/10/28 11:48
MHDA- 2023/11/13 06:42
CRDT- 2023/10/28 05:26
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/10/28 11:48 [pubmed]
PHST- 2023/10/28 05:26 [entrez]
AID - 10.1080/10934529.2023.2273690 [doi]
PST - ppublish
SO  - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2023;58(12):954-962. doi: 
      10.1080/10934529.2023.2273690. Epub 2023 Nov 10.