PMID- 37898973
OWN - NLM
STAT- MEDLINE
DCOM- 20240206
LR  - 20240206
IS  - 1099-0968 (Electronic)
IS  - 1072-4133 (Linking)
VI  - 32
IP  - 2
DP  - 2024 Mar
TI  - A longitudinal study of autism spectrum disorder characteristics in adolescents 
      with restrictive type anorexia nervosa during and after underweight.
PG  - 310-321
LID - 10.1002/erv.3042 [doi]
AB  - OBJECTIVES: This prospective, longitudinal study aims to compare the prevalence 
      of autism spectrum disorder (ASD) characteristics in adolescents with anorexia 
      nervosa (AN) during and after underweight in order to help unravel the complex 
      link between both conditions. METHODS: 24 adolescents with AN completed the youth 
      self-report, autism spectrum quotient (AQ) or autism spectrum quotient adolescent 
      version (AQ - adolescent) and a questionnaire designed by the researchers during 
      a state of underweight and after weight recovery. RESULTS: AQ total score and 
      several AQ subscale scores at the time of underweight are significantly higher 
      than after weight recovery with medium to large effect sizes. Linear modelling 
      cannot prove a significant effect of weight gain, internalizing problems or 
      medication use on AQ score, but it does show an association between AQ during 
      underweight and AQ after weight recovery. CONCLUSIONS: The results highlight the 
      complexity of the link between AN and ASD characteristics. Although a clear 
      change in AQ score is seen in part of the participants, this effect cannot be 
      generalized and a link with weight change cannot be demonstrated. It seems likely 
      that ASD characteristics in AN are a combination of trait and state: underweight 
      and starvation might exacerbate potentially present traits. Part of our results 
      may indicate the existence of subgroups based on AQ score during underweight. Our 
      study supports the theory that more ASD characteristics at T1 may result in a 
      poorer outcome and a higher need for specified and intensive treatment.
CI  - (c) 2023 Eating Disorders Association and John Wiley & Sons Ltd.
FAU - Nuyttens, Marieke
AU  - Nuyttens M
AUID- ORCID: 0009-0009-0456-0930
AD  - Ghent University, Faculty of Medicine and Health Sciences, Ghent, Belgium.
FAU - Simons, Annik
AU  - Simons A
AD  - Department for Child and Adolescent Psychiatry, Antwerp University Hospital, 
      Antwerp, Belgium.
FAU - Antrop, Inge
AU  - Antrop I
AD  - Ghent University, Faculty of Medicine and Health Sciences, Ghent, Belgium.
FAU - Glazemakers, Inge
AU  - Glazemakers I
AD  - Antwerp University, Faculty of Medicine and Health Sciences, Antwerp, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20231029
PL  - England
TA  - Eur Eat Disord Rev
JT  - European eating disorders review : the journal of the Eating Disorders 
      Association
JID - 9436977
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - *Autism Spectrum Disorder/epidemiology
MH  - *Anorexia Nervosa/complications/epidemiology/therapy
MH  - Longitudinal Studies
MH  - Thinness/epidemiology
MH  - Prospective Studies
OTO - NOTNLM
OT  - anorexia nervosa
OT  - autism spectrum disorder
OT  - autism spectrum quotient
OT  - internalizing problems
OT  - longitudinal design
EDAT- 2023/10/29 18:41
MHDA- 2024/02/06 06:42
CRDT- 2023/10/29 15:07
PHST- 2023/09/16 00:00 [revised]
PHST- 2023/05/27 00:00 [received]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2024/02/06 06:42 [medline]
PHST- 2023/10/29 18:41 [pubmed]
PHST- 2023/10/29 15:07 [entrez]
AID - 10.1002/erv.3042 [doi]
PST - ppublish
SO  - Eur Eat Disord Rev. 2024 Mar;32(2):310-321. doi: 10.1002/erv.3042. Epub 2023 Oct 
      29.