PMID- 37899073
OWN - NLM
STAT- Publisher
LR  - 20231123
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
DP  - 2023 Oct 29
TI  - Pilot study on anti-reflux mucoplasty: Advancing endoscopic anti-reflux therapy 
      for gastroesophageal reflux disease.
LID - 10.1111/den.14711 [doi]
AB  - OBJECTIVES: Anti-reflux mucosectomy (ARMS) and anti-reflux mucosal ablation 
      (ARMA) were developed as interventions for proton pump inhibitor 
      (PPI)-refractory/-dependent gastroesophageal reflux disease (GERD). Although ARMS 
      and ARMA are established treatments for PPI-refractory GERD, reliance on natural 
      healing for ulcer scar formation introduces uncertainty and bleeding risk. To 
      address these issues, we introduced a novel approach called anti-reflux 
      mucoplasty (ARM-P), which involves immediate closure of mucosal defects following 
      mucosectomy. This pilot study aims to evaluate the safety, feasibility, and 
      efficacy of ARM-P. METHODS: A retrospective single-center study was conducted 
      using prospectively collected data from October 2022 to July 2023. Patients with 
      PPI-refractory/-dependent GERD who underwent ARM-P were included. The study 
      evaluated technical success of ARM-P, before and after ARM-P GERD-Health Related 
      Quality of Life Questionnaire, GerdQ, and Frequency Scale for the Symptoms of 
      GERD scores, along with PPI discontinuation and endoscopic esophagogastric 
      junction morphology. RESULTS: A total of 20 patients with a median age of 
      61.5 years underwent the ARM-P procedure. The procedure achieved 100% technical 
      success without adverse events. After ARM-P, 55.0% discontinued PPI usage and 
      15.0% reduced PPI dose by half. Median GERD-Health Related Quality of Life 
      Questionnaire score improved from 21 to 6 (P = 0.0026), median GerdQ score 
      improved from 9 to 7 (P = 0.0022), and median Frequency Scale for the Symptoms of 
      GERD score decreased from 16 to 7 (P = 0.0003). Median Hill's Classification 
      significantly improved from grade III to grade I (P = 0.0001). CONCLUSIONS: This 
      study presents the first pilot report of ARM-P, demonstrating its procedural 
      safety, technical feasibility, and short-term efficacy.
CI  - (c) 2023 The Authors. Digestive Endoscopy published by John Wiley & Sons Australia, 
      Ltd on behalf of Japan Gastroenterological Endoscopy Society.
FAU - Inoue, Haruhiro
AU  - Inoue H
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Yamamoto, Kazuki
AU  - Yamamoto K
AUID- ORCID: 0000-0001-6614-2763
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Shimamura, Yuto
AU  - Shimamura Y
AUID- ORCID: 0000-0003-4107-9264
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Azuma, Daisuke
AU  - Azuma D
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Ushikubo, Kei
AU  - Ushikubo K
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Okada, Hiroki
AU  - Okada H
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Kimoto, Yoshiaki
AU  - Kimoto Y
AUID- ORCID: 0000-0003-4813-342X
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Nishikawa, Yohei
AU  - Nishikawa Y
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Tanaka, Ippei
AU  - Tanaka I
AUID- ORCID: 0000-0001-8776-6663
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Tanabe, Mayo
AU  - Tanabe M
AUID- ORCID: 0000-0001-6126-5684
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Onimaru, Manabu
AU  - Onimaru M
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Navarro, Marc Julius
AU  - Navarro MJ
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
AD  - Institute of Digestive and Liver Diseases, St. Luke's Medical Center, Quezon 
      City, Philippines.
LA  - eng
PT  - Journal Article
DEP - 20231029
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
SB  - IM
OTO - NOTNLM
OT  - anti-reflux mucoplasty
OT  - anti-reflux mucosal ablation
OT  - anti-reflux mucosectomy
OT  - endoscopic anti-reflux therapy
OT  - gastroesophageal reflux disease
EDAT- 2023/10/30 00:41
MHDA- 2023/10/30 00:41
CRDT- 2023/10/29 20:32
PHST- 2023/08/08 00:00 [received]
PHST- 2023/10/22 00:00 [accepted]
PHST- 2023/10/30 00:41 [pubmed]
PHST- 2023/10/30 00:41 [medline]
PHST- 2023/10/29 20:32 [entrez]
AID - 10.1111/den.14711 [doi]
PST - aheadofprint
SO  - Dig Endosc. 2023 Oct 29. doi: 10.1111/den.14711.