PMID- 37899196
OWN - NLM
STAT- MEDLINE
DCOM- 20231031
LR  - 20231031
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 64
IP  - 9
DP  - 2023
TI  - [Clinical significance of human leukocyte antigen incompatibility in allogeneic 
      hematopoietic stem cell transplantation].
PG  - 1158-1165
LID - 10.11406/rinketsu.64.1158 [doi]
AB  - The use of human leukocyte antigen (HLA)-incompatible transplantations, in 
      addition to cord blood transplantation, is rapidly increasing due to the 
      development and refinement of graft-versus-host disease prophylactic treatment 
      with post-transplant cyclophosphamide or anti-thymocyte globulin. However, 
      caution must be observed in interpretating the significance of HLA 
      incompatibility because each transplant source differs, which affect the 
      association between HLA compatibility and transplant outcome. In addition, the 
      loci that should be evaluated, the level of matching (antigen/allele), the 
      direction of incompatibility (graft-versus-host or host-versus-graft), and the 
      combination of incompatible HLA alleles must be understood. Notably, the 
      significance of HLA incompatibility changes with the development and improvement 
      of GVHD prophylactic treatment. Factors that should be prioritized in donor 
      selection should be evaluated in the future. This article outlines the 
      significance of HLA incompatibility in each transplant source.
FAU - Kanda, Junya
AU  - Kanda J
AD  - Department of Hematology, Kyoto University Hospital.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - Clinical Relevance
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Transplantation, Homologous/adverse effects
MH  - *Graft vs Host Disease/etiology
MH  - Histocompatibility
MH  - HLA Antigens/genetics
OTO - NOTNLM
OT  - Allogeneic stem cell transplantation
OT  - Cord blood transplantation
OT  - HLA matching
OT  - Related transplantation
OT  - Unrelated transplantation
EDAT- 2023/10/30 00:41
MHDA- 2023/10/31 06:42
CRDT- 2023/10/29 21:38
PHST- 2023/10/31 06:42 [medline]
PHST- 2023/10/30 00:41 [pubmed]
PHST- 2023/10/29 21:38 [entrez]
AID - 10.11406/rinketsu.64.1158 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2023;64(9):1158-1165. doi: 10.11406/rinketsu.64.1158.