PMID- 37899404
OWN - NLM
STAT- MEDLINE
DCOM- 20231031
LR  - 20231121
IS  - 1008-9292 (Print)
IS  - 1008-9292 (Linking)
VI  - 52
IP  - 5
DP  - 2023 Oct 25
TI  - Research progress on the roles of neurovascular unit in stroke-induced 
      immunosuppression.
PG  - 662-672
LID - 1008-9292(2023)05-0662-11 [pii]
LID - 10.3724/zdxbyxb-2023-0144 [doi]
AB  - A complex pathophysiological mechanism is involved in brain injury following 
      cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular 
      structure consisting of neurons, endothelial cells, pericyte, astrocyte, 
      microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly 
      participates in the regulation of inflammatory immune process. The components of 
      NVU promote inflammatory overreaction and synergize with the overactivation of 
      autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID 
      can alleviate the damage caused by inflammation, however, it also makes stroke 
      patients more susceptible to infection, leading to systemic damage. This article 
      reviews the mechanism of SIID and the roles of NVU in SIID, to provide a 
      perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral 
      infarction.
FAU - Zhou, Mengqin
AU  - Zhou M
AD  - Institute of Translational Medicine, Yangzhou University Medical College, 
      Yangzhou 225009, Jiangsu Province, China. zhoumengq199@163.com.
FAU - Su, Peng
AU  - Su P
AD  - Institute of Translational Medicine, Yangzhou University Medical College, 
      Yangzhou 225009, Jiangsu Province, China.
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, 
      China.
FAU - Liang, Jingyan
AU  - Liang J
AD  - Institute of Translational Medicine, Yangzhou University Medical College, 
      Yangzhou 225009, Jiangsu Province, China.
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, 
      China.
FAU - Xiong, Tianqing
AU  - Xiong T
AD  - Institute of Translational Medicine, Yangzhou University Medical College, 
      Yangzhou 225009, Jiangsu Province, China. xiongtianqing@126.com.
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Diseases, Yangzhou 225009, Jiangsu Province, 
      China. xiongtianqing@126.com.
LA  - chi
LA  - eng
PT  - Journal Article
PT  - Review
TT  - 神经血管单元与脑梗死后免疫抑制研究进展.
PL  - China
TA  - Zhejiang Da Xue Xue Bao Yi Xue Ban
JT  - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical 
      sciences
JID - 100927946
SB  - IM
MH  - Humans
MH  - *Endothelial Cells
MH  - *Stroke
MH  - Neurons/physiology
MH  - Immunosuppression Therapy/adverse effects
MH  - Cerebral Infarction
PMC - PMC10630064
OAB - A complex pathophysiological mechanism is involved in brain injury following 
      cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular 
      structure consisting of neurons, endothelial cells, pericyte, astrocyte, 
      microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly 
      participates in the regulation of inflammatory immune process. The components of 
      NVU promote inflammatory overreaction and synergize with the overactivation of 
      autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID 
      can alleviate the damage caused by inflammation, however, it also makes stroke 
      patients more susceptible to infection, leading to systemic damage. This article 
      reviews the mechanism of SIID and the roles of NVU in SIID, to provide a 
      perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral 
      infarction.
OABL- eng
OTO - NOTNLM
OT  - Cerebral infarction
OT  - Immunosuppression
OT  - Neurovascular unit
OT  - Review
COIS- 所有作者均声明不存在利益冲突 The authors declare that there is no conflict of interests
EDAT- 2023/10/30 06:47
MHDA- 2023/10/31 06:42
PMCR- 2023/10/25
CRDT- 2023/10/30 00:07
PHST- 2023/10/31 06:42 [medline]
PHST- 2023/10/30 06:47 [pubmed]
PHST- 2023/10/30 00:07 [entrez]
PHST- 2023/10/25 00:00 [pmc-release]
AID - 1008-9292(2023)05-0662-11 [pii]
AID - 10.3724/zdxbyxb-2023-0144 [doi]
PST - ppublish
SO  - Zhejiang Da Xue Xue Bao Yi Xue Ban. 2023 Oct 25;52(5):662-672. doi: 
      10.3724/zdxbyxb-2023-0144.