PMID- 37900276
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 11
DP  - 2023
TI  - Regenerative potential of mesenchymal stromal cells in wound healing: unveiling 
      the influence of normoxic and hypoxic environments.
PG  - 1245872
LID - 10.3389/fcell.2023.1245872 [doi]
LID - 1245872
AB  - The innate and adaptive immune systems rely on the skin for various purposes, 
      serving as the primary defense against harmful environmental elements. However, 
      skin lesions may lead to undesirable consequences such as scarring, accelerated 
      skin aging, functional impairment, and psychological effects over time. The 
      rising popularity of mesenchymal stromal cells (MSCs) for skin wound treatment is 
      due to their potential as a promising therapeutic option. MSCs offer advantages 
      in terms of differentiation capacity, accessibility, low immunogenicity, and 
      their central role in natural wound-healing processes. To accelerate the healing 
      process, MSCs promote cell migration, angiogenesis, epithelialization, and 
      granulation tissue development. Oxygen plays a critical role in the formation and 
      expansion of mammalian cells. The term "normoxia" refers to the usual oxygen 
      levels, defined at 20.21 percent oxygen (160 mm of mercury), while "hypoxia" 
      denotes oxygen levels of 2.91 percent or less. Notably, the ambient O(2) content 
      (20%) in the lab significantly differs from the 2%-9% O(2) concentration in their 
      natural habitat. Oxygen regulation of hypoxia-inducible factor-1 (HIF-1) mediated 
      expression of multiple genes plays a crucial role in sustaining stem cell destiny 
      concerning proliferation and differentiation. This study aims to elucidate the 
      impact of normoxia and hypoxia on MSC biology and draw comparisons between the 
      two. The findings suggest that expanding MSC-based regenerative treatments in a 
      hypoxic environment can enhance their growth kinetics, genetic stability, and 
      expression of chemokine receptors, ultimately increasing their effectiveness.
CI  - Copyright (c) 2023 Mahjoor, Fakouri, Farokhi, Nazari, Afkhami and Heidari.
FAU - Mahjoor, Mohamad
AU  - Mahjoor M
AD  - Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 
      Iran.
AD  - Department of Immunology, Faculty of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Fakouri, Arshia
AU  - Fakouri A
AD  - Student Research Committee, USERN Office, Lorestan University of Medical 
      Sciences, Khorramabad, Iran.
FAU - Farokhi, Simin
AU  - Farokhi S
AD  - Student Research Committee, USERN Office, Lorestan University of Medical 
      Sciences, Khorramabad, Iran.
FAU - Nazari, Hojjatollah
AU  - Nazari H
AD  - School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 
      Australia.
FAU - Afkhami, Hamed
AU  - Afkhami H
AD  - Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 
      Iran.
AD  - Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, 
      Semnan, Iran.
AD  - Department of Medical Microbiology, Faculty of Medicine, Shahed University, 
      Tehran, Iran.
FAU - Heidari, Fatemeh
AU  - Heidari F
AD  - Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 
      Iran.
AD  - Department of Anatomy, Faculty of Medicine, Qom University of Medical Sciences, 
      Qom, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231010
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC10603205
OTO - NOTNLM
OT  - hypoxic MSCs
OT  - mesenchymal stromal/stem cells (MSCs)
OT  - normoxic MSCs
OT  - wound
OT  - wound healing
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/30 06:46
MHDA- 2023/10/30 06:47
PMCR- 2023/01/01
CRDT- 2023/10/30 04:32
PHST- 2023/06/23 00:00 [received]
PHST- 2023/08/11 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/30 06:46 [pubmed]
PHST- 2023/10/30 04:32 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1245872 [pii]
AID - 10.3389/fcell.2023.1245872 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2023 Oct 10;11:1245872. doi: 10.3389/fcell.2023.1245872. 
      eCollection 2023.