PMID- 37900282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 11
DP  - 2023
TI  - Dendritic cells in liver transplantation immune response.
PG  - 1277743
LID - 10.3389/fcell.2023.1277743 [doi]
LID - 1277743
AB  - Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they 
      are considered one of the key regulatory factors in the liver immune system. 
      There is currently much interest in modulating DC function to improve transplant 
      immune response. In liver transplantation, DCs participate in both the promotion 
      and inhibition of the alloreponse by adopting different phenotypes and function. 
      Thus, in this review, we discussed the origin, maturation, migration and 
      pathological effects of several DC subsets, including the conventional DC (cDC), 
      plasmacytoid DC (pDC) and monocyte-derived DC (Mo-DC) in liver transplantation, 
      and we summarized the roles of these DC subsets in liver transplant rejection and 
      tolerance. In addition, we also outlined the latest progress in DC-based related 
      treatment regimens. Overall, our discussion provides a beneficial resource for 
      better understanding the biology of DCs and their manipulation to improve the 
      immune adaptability of patients in transplant status.
CI  - Copyright (c) 2023 Du, Li, Huan and Lv.
FAU - Du, Xiaodong
AU  - Du X
AD  - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The 
      First Hospital of Jilin University, Changchun, China.
FAU - Li, Mingqian
AU  - Li M
AD  - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The 
      First Hospital of Jilin University, Changchun, China.
FAU - Huan, Chen
AU  - Huan C
AD  - Center of Infectious Diseases and Pathogen Biology, Institute of Virology and 
      AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The 
      Ministry of Education, The First Hospital of Jilin University, Changchun, China.
FAU - Lv, Guoyue
AU  - Lv G
AD  - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The 
      First Hospital of Jilin University, Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231013
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC10606587
OTO - NOTNLM
OT  - DC based treatment
OT  - dendritic cells
OT  - immune rejection
OT  - immune tolerance
OT  - liver transplantation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/30 06:46
MHDA- 2023/10/30 06:47
PMCR- 2023/01/01
CRDT- 2023/10/30 04:32
PHST- 2023/08/15 00:00 [received]
PHST- 2023/09/27 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/30 06:46 [pubmed]
PHST- 2023/10/30 04:32 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1277743 [pii]
AID - 10.3389/fcell.2023.1277743 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2023 Oct 13;11:1277743. doi: 10.3389/fcell.2023.1277743. 
      eCollection 2023.