PMID- 37900537
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 9
DP  - 2023 Sep
TI  - The Association of Dyslipidemia and Atherogenic Indices With Glycemic Control in 
      Diabetic Dyslipidemia Patients: A Real-World Landscape.
PG  - e45985
LID - 10.7759/cureus.45985 [doi]
LID - e45985
AB  - BACKGROUND: Dyslipidemia is an important comorbid factor of type 2 diabetes 
      mellitus (T2DM) that increases the risk of cardiovascular diseases. This study 
      aimed to assess the pattern of dyslipidemia and atherogenic indices and determine 
      its relation with glycemic control. METHODS: A cross-sectional study enrolled 382 
      patients with diabetic dyslipidemia. The socio-demographics data, clinical 
      features, and laboratory parameters were collected. The baseline lipid parameters 
      such as total cholesterol (TC), triglyceride (TG), low-density lipoprotein 
      cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and glycated 
      hemoglobin (HbA1C) were measured. Atherogenic indices such as TC/HDL-C ratio, 
      TG/HDL-C ratio, LDL-C/HDL-C ratio, non-HDL-C/HDL-C and atherogenic index of 
      plasma (AIP) [log10 (TG/HDL-C)] were calculated. T2DM patients were classified 
      into three groups based on the degree of glycemic control: Good glycemic control 
      (HbA1C<7%), fair control (HbA1C 7-8%), and poor control (HbA1C>8%). RESULTS: The 
      population's mean age was 48.60+/-6.15 years, with 145 (38%) males. We found mixed 
      dyslipidemia as the most prevalent (36.1%) form of dyslipidemia in our patients. 
      The most common pattern in atherogenic indices was AIP (94.2%). HbA1c was 
      positively correlated with duration of diabetes (r=0.253, p<0.001). In 
      multivariate logistic regression analysis, duration of diabetes (>10 years) was 
      significantly associated with poor glycemic control with an odds ratio (OR) of 
      2.31(95% CI; 1.25-4.24, p=0.007). CONCLUSION: The present study indicated that 
      neither the pattern of dyslipidemia nor the atherogenic indices were markers of 
      poor glycemic control among South Indian patients attending our tertiary care 
      institute. However, duration of diabetes was significantly associated with poor 
      glycemic control.
CI  - Copyright (c) 2023, Bage et al.
FAU - Bage, Isaac J
AU  - Bage IJ
AD  - Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
FAU - Kamalanathan, Sadishkumar
AU  - Kamalanathan S
AD  - Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
FAU - Selvarajan, Sandhiya
AU  - Selvarajan S
AD  - Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
FAU - Sahoo, Jayaprakash
AU  - Sahoo J
AD  - Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
FAU - Jayanthi, Mathaiyan
AU  - Jayanthi M
AD  - Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
FAU - Naik, Dukhabandhu
AU  - Naik D
AD  - Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and 
      Research, Puducherry, IND.
LA  - eng
PT  - Journal Article
DEP - 20230926
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10601505
OTO - NOTNLM
OT  - atherogenic indices
OT  - diabetic dyslipidemia
OT  - glycemic control
OT  - hba1c
OT  - pattern of dyslipidemia
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/10/30 06:46
MHDA- 2023/10/30 06:47
PMCR- 2023/09/26
CRDT- 2023/10/30 04:35
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/30 06:46 [pubmed]
PHST- 2023/10/30 04:35 [entrez]
PHST- 2023/09/26 00:00 [pmc-release]
AID - 10.7759/cureus.45985 [doi]
PST - epublish
SO  - Cureus. 2023 Sep 26;15(9):e45985. doi: 10.7759/cureus.45985. eCollection 2023 
      Sep.