PMID- 37901393
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Disease progression in patients with usual interstitial pneumonia and probable 
      UIP patterns on computed tomography with various underlying etiologies: a 
      retrospective cohort study.
PG  - 1246767
LID - 10.3389/fmed.2023.1246767 [doi]
LID - 1246767
AB  - BACKGROUND: Usual interstitial pneumonia (UIP) is a pattern of interstitial 
      pneumonia that is caused by different etiologies. This study aimed to investigate 
      the transplant-free survival (TFS) and the decline in forced vital capacity (FVC) 
      of the patients with UIP and probable UIP patterns on CT caused by various 
      underlying conditions. METHODS: A retrospective cohort study was conducted, 
      enrolling patients with interstitial lung disease exhibiting a CT pattern 
      consistent with UIP or probable UIP. Clinical and prognostic data of patients 
      categorized by the etiology were compared. RESULTS: A total of 591 patients were 
      included and classified into the following groups: idiopathic pulmonary fibrosis 
      (IPF) (n = 320), connective tissue disease (CTD)-UIP (n = 229), asbestosis-UIP 
      (n = 28), and hypersensitivity pneumonitis (HP)-UIP (n = 14). Advanced age, 
      elevated levels of serum cytokeratin fraction 21-1 and percentage of neutrophils 
      in bronchoalveolar lavage were observed in all groups. IPF patients showed a more 
      rapid decline in FVC (133.9 mL/year) compared to CTD-UIP (24.5 mL/year, 
      p = 0.001) and asbestosis-UIP (61.0 mL/year, p = 0.008) respectively. 
      Sub-analysis of CTD-UIP revealed that patients with rheumatoid arthritis (RA)-UIP 
      (88.1 mL/year) or antineutrophil cytoplasmic antibody-associated vasculitis 
      (AAV)-UIP (72.9 mL/year) experienced a faster deterioration in FVC compared to 
      those with primary Sjogren's syndrome (pSS)-UIP (25.9 mL/year, p < 0.05). 
      Kaplan-Meier curves showed that IPF had the poorest TFS (median 55.9 months), 
      followed by HP-UIP (57.5 months), CTD-UIP (66.7 months), and asbestosis-UIP (TFS 
      not reached). RA-UIP or AAV-UIP did not exhibit any prognostic advantages 
      compared to IPF, while asbestosis-UIP and pSS-UIP showed better survival rates. 
      CONCLUSION: Patients with UIP caused by different underlying conditions share 
      certain common features, but the trajectories of disease progression and survival 
      outcomes differ.
CI  - Copyright (c) 2023 Yang, Wang, Sun, Wang, Xue and Ye.
FAU - Yang, Shuqiao
AU  - Yang S
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Sun, Di
AU  - Sun D
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Occupational Medicine and Toxicology, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Wang, Yiran
AU  - Wang Y
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Occupational Medicine and Toxicology, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Xue, Changjiang
AU  - Xue C
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Occupational Medicine and Toxicology, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
FAU - Ye, Qiao
AU  - Ye Q
AD  - Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory 
      Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
AD  - Department of Occupational Medicine and Toxicology, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20231012
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10601466
OTO - NOTNLM
OT  - etiology
OT  - idiopathic pulmonary fibrosis
OT  - pulmonary function
OT  - transplant-free survival
OT  - usual interstitial pneumonia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/30 06:46
MHDA- 2023/10/30 06:47
PMCR- 2023/10/12
CRDT- 2023/10/30 04:52
PHST- 2023/06/24 00:00 [received]
PHST- 2023/10/02 00:00 [accepted]
PHST- 2023/10/30 06:47 [medline]
PHST- 2023/10/30 06:46 [pubmed]
PHST- 2023/10/30 04:52 [entrez]
PHST- 2023/10/12 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1246767 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Oct 12;10:1246767. doi: 10.3389/fmed.2023.1246767. 
      eCollection 2023.