PMID- 37903435
OWN - NLM
STAT- MEDLINE
DCOM- 20231215
LR  - 20240119
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 109
IP  - 6
DP  - 2023 Dec 6
TI  - Cytokine and Chemokine Profiles in Acute Severe Fever with Thrombocytopenia 
      Syndrome and Scrub Typhus in South Korea.
PG  - 1311-1318
LID - 10.4269/ajtmh.23-0146 [doi]
AB  - In East Asia, severe fever with thrombocytopenia syndrome (SFTS) and scrub 
      typhus, which are common endemic tick- and mite-mediated diseases sharing common 
      clinical manifestations, are becoming public health concerns. However, there are 
      limited data on the comparative immunopathogenesis between the two diseases. We 
      compared the cytokine profiles of SFTS and scrub typhus to further elucidate 
      immune responses that occur during the disease courses. We prospectively enrolled 
      44 patients with confirmed SFTS and 49 patients with scrub typhus from July 2015 
      to December 2020. In addition, 10 healthy volunteers were enrolled as healthy 
      controls. A cytometric bead array was used to analyze plasma samples for 16 
      cytokines. A total of 68 plasma samples, including 31 (45.6%) from patients with 
      SFTS and 37 (54.4%) from patients with scrub typhus, were available for cytokine 
      measurement. There were three cytokine expression patterns: increased levels in 
      both SFTS and scrub typhus (interleukin 6 [IL-6], IL-10, interferon gamma induced 
      protein 10 [IP-10], and granulocyte-macrophage colony-stimulating factor 
      [GM-CSF]), highest levels in SFTS (interferon alpha [IFN-alpha], IFN-gamma, 
      granulocyte-CSF [G-CSF], monocyte chemotactic protein 1 [MCP-1], macrophage 
      inflammatory protein 1alpha [MIP-1alpha], and IL-8), and distinct levels in scrub typhus 
      (IL-12p40, tumor necrosis factor alpha [TNFalpha], IL-1beta, regulated on activation and 
      normally T-cell expressed and secreted [RANTES], IL-17A, and vascular endothelial 
      growth factor [VEGF]). Although patients with acute SFTS and scrub typhus 
      exhibited partly shared expression patterns of cytokines related to disease 
      severity, the different profiles of cytokines and chemokines might contribute to 
      higher mortality in SFTS than in scrub typhus. Discrete patterns of helper T 
      cell-related cytokines and VEGF might reflect differences in CD4 T-cell responses 
      and vascular damage between these diseases.
FAU - Kwon, Ji-Soo
AU  - Kwon JS
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Republic of Korea.
FAU - Hong, Sun In
AU  - Hong SI
AD  - Division of Infectious Diseases, Soonchunhyang University Cheonan Hospital, 
      Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.
FAU - Kim, Ji Yeun
AU  - Kim JY
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Republic of Korea.
FAU - Cha, Hye Hee
AU  - Cha HH
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Taeeun
AU  - Kim T
AD  - Division of Infectious Diseases, Gyeongsang National University Hospital, 
      Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
FAU - Park, Se Yoon
AU  - Park SY
AD  - Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang 
      University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Min-Chul
AU  - Kim MC
AD  - Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang 
      University Hospital, Seoul, Republic of Korea.
FAU - Park, Seong Yeon
AU  - Park SY
AD  - Department of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, 
      Republic of Korea.
FAU - Choi, Seong-Ho
AU  - Choi SH
AD  - Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang 
      University Hospital, Seoul, Republic of Korea.
FAU - Chung, Jin-Won
AU  - Chung JW
AD  - Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang 
      University Hospital, Seoul, Republic of Korea.
FAU - Kim, Sung-Han
AU  - Kim SH
AD  - Department of Infectious Diseases, Asan Medical Center, University of Ulsan 
      College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20231030
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Humans
MH  - Chemokines
MH  - Cytokines
MH  - *Phlebovirus
MH  - Republic of Korea
MH  - *Scrub Typhus
MH  - *Severe Fever with Thrombocytopenia Syndrome
MH  - Vascular Endothelial Growth Factor A
MH  - Prospective Studies
PMC - PMC10793061
EDAT- 2023/10/31 00:42
MHDA- 2023/12/11 12:41
PMCR- 2024/12/01
CRDT- 2023/10/30 18:32
PHST- 2023/03/19 00:00 [received]
PHST- 2023/09/08 00:00 [accepted]
PHST- 2024/12/01 00:00 [pmc-release]
PHST- 2023/12/11 12:41 [medline]
PHST- 2023/10/31 00:42 [pubmed]
PHST- 2023/10/30 18:32 [entrez]
AID - tpmd230146 [pii]
AID - 10.4269/ajtmh.23-0146 [doi]
PST - epublish
SO  - Am J Trop Med Hyg. 2023 Oct 30;109(6):1311-1318. doi: 10.4269/ajtmh.23-0146. 
      Print 2023 Dec 6.