PMID- 37903594
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240119
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 43
IP  - 50
DP  - 2023 Dec 13
TI  - Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of 
      Social Chemosignals in the Mouse Accessory Olfactory Bulb.
PG  - 8700-8722
LID - 10.1523/JNEUROSCI.1055-23.2023 [doi]
AB  - Social communication is crucial for the survival of many species. In most 
      vertebrates, a dedicated chemosensory system, the vomeronasal system (VNS), 
      evolved to process ethologically relevant chemosensory cues. The first central 
      processing stage of the VNS is the accessory olfactory bulb (AOB), which sends 
      information to downstream brain regions via AOB mitral cells (AMCs). Recent 
      studies provided important insights about the functional properties of AMCs, but 
      little is known about the principles that govern their coordinated activity. 
      Here, we recorded local field potentials (LFPs) and single-unit activity in the 
      AOB of adult male and female mice during presentation of natural stimuli. Our 
      recordings reveal prominent LFP theta-band oscillatory episodes with a 
      characteristic spatial pattern across the AOB. Throughout an experiment, the AOB 
      network shows varying degrees of similarity to this pattern, in a manner that 
      depends on the sensory stimulus. Analysis of LFP signal polarity and single-unit 
      activity indicates that oscillatory episodes are generated locally within the 
      AOB, likely representing a reciprocal interaction between AMCs and granule cells. 
      Notably, spike times of many AMCs are constrained to the negative LFP oscillation 
      phase in a manner that can drastically affect integration by downstream 
      processing stages. Based on these observations, we propose that LFP oscillations 
      may gate, bind, and organize outgoing signals from individual AOB neurons to 
      downstream processing stages. Our findings suggest that, as in other neuronal 
      systems and brain regions, population-level oscillations play a key role in 
      organizing and enhancing transmission of socially relevant chemosensory 
      information.SIGNIFICANCE STATEMENT The accessory olfactory bulb (AOB) is the 
      first central stage of the vomeronasal system, a chemosensory system dedicated to 
      processing cues from other organisms. Information from the AOB is conveyed to 
      other brain regions via activity of its principal neurons, AOB mitral cells 
      (AMCs). Here, we show that socially relevant sensory stimulation of the mouse 
      vomeronasal system leads not only to changes in AMC activity, but also to 
      distinct theta-band ( approximately 5 Hz) oscillatory episodes in the local field potential. 
      Notably AMCs favor the negative phase of these oscillatory events. Our findings 
      suggest a novel mechanism for the temporal coordination of distributed patterns 
      of neuronal activity, which can serve to efficiently activate downstream 
      processing stages.
CI  - Copyright (c) 2023 the authors.
FAU - Cohen, Oksana
AU  - Cohen O
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, 
      Israel.
FAU - Kahan, Anat
AU  - Kahan A
AUID- ORCID: 0000-0002-4799-3017
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, 
      Israel.
AD  - Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food 
      and Environment, The Hebrew University, Rehovot 7610001, Israel.
FAU - Steinberg, Idan
AU  - Steinberg I
AD  - Alpha Program, Future Scientist Center, The Hebrew University Youth Division, 
      Jerusalem 9190401, Israel.
FAU - Malinowski, Sebastian T
AU  - Malinowski ST
AD  - Department of Chemosensation, Institute for Biology II, RWTH Aachen University, 
      52062 Aachen, Germany.
FAU - Rokni, Dan
AU  - Rokni D
AUID- ORCID: 0000-0002-3041-8462
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, 
      Israel.
FAU - Spehr, Marc
AU  - Spehr M
AUID- ORCID: 0000-0001-6616-4196
AD  - Department of Chemosensation, Institute for Biology II, RWTH Aachen University, 
      52062 Aachen, Germany.
FAU - Ben-Shaul, Yoram
AU  - Ben-Shaul Y
AUID- ORCID: 0000-0002-0407-4221
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, 
      Israel yoramb@ekmd.huji.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231213
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Mice
MH  - Male
MH  - Female
MH  - Animals
MH  - *Olfactory Bulb/physiology
MH  - *Neurons/physiology
MH  - Cues
PMC - PMC10727196
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - chemosensation
OT  - local field potentials
OT  - theta oscillations
OT  - vomeronsal system
EDAT- 2023/10/31 00:42
MHDA- 2023/12/17 09:45
PMCR- 2024/06/13
CRDT- 2023/10/30 21:22
PHST- 2023/06/07 00:00 [received]
PHST- 2023/10/13 00:00 [revised]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2024/06/13 00:00 [pmc-release]
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/10/31 00:42 [pubmed]
PHST- 2023/10/30 21:22 [entrez]
AID - JNEUROSCI.1055-23.2023 [pii]
AID - JN-RM-1055-23 [pii]
AID - 10.1523/JNEUROSCI.1055-23.2023 [doi]
PST - epublish
SO  - J Neurosci. 2023 Dec 13;43(50):8700-8722. doi: 10.1523/JNEUROSCI.1055-23.2023.