PMID- 37903711
OWN - NLM
STAT- MEDLINE
DCOM- 20240415
LR  - 20240415
IS  - 1499-3872 (Print)
VI  - 23
IP  - 3
DP  - 2024 Jun
TI  - Indications of pro-inflammatory cytokines in laparoscopic and open liver 
      resection for early-stage hepatocellular carcinoma.
PG  - 257-264
LID - S1499-3872(23)00180-7 [pii]
LID - 10.1016/j.hbpd.2023.10.006 [doi]
AB  - BACKGROUND: Our clinical practice of laparoscopic liver resection (LLR) had 
      achieved better short-term and long-term benefits for patients with 
      hepatocellular carcinoma (HCC) over open liver resection (OLR), but the 
      underlying mechanisms are not clear. This study was to find out whether systemic 
      inflammation plays an important role. METHODS: A total of 103 patients with 
      early-stage HCC under liver resection were enrolled (LLR group, n = 53; OLR 
      group, n = 50). The expression of 9 inflammatory cytokines in patients at 
      preoperation, postoperative day 1 (POD1) and POD7 was quantified by Luminex 
      Multiplex assay. The relationships of the cytokines and the postoperative 
      outcomes were compared between LLR and OLR. RESULTS: Seven of the circulating 
      cytokines were found to be significantly upregulated on POD1 after LLR or OLR 
      compared to their preoperative levels. Compared to OLR, the POD1 levels of 
      granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), 
      IL-8, and monocyte chemoattractant protein-1 (MCP-1) in the LLR group were 
      significantly lower. Higher POD1 levels of these cytokines were significantly 
      correlated with longer operative time and higher volume of blood loss during 
      operation. The levels of these cytokines were positively associated with 
      postoperative liver injury, and the length of hospital stay. Importantly, a high 
      level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free 
      survival after liver resection. CONCLUSIONS: Significantly lower level of GM-CSF, 
      IL-6, IL-8, and MCP-1 after liver resection represented a milder systemic 
      inflammation which might be an important mechanism to offer better short-term and 
      long-term outcomes in LLR over OLR.
CI  - Copyright (c) 2023 First Affiliated Hospital, Zhejiang University School of 
      Medicine in China. Published by Elsevier B.V. All rights reserved.
FAU - Ng, Kevin Tak-Pan
AU  - Ng KT
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Pang, Li
AU  - Pang L
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Wang, Jia-Qi
AU  - Wang JQ
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - She, Wong Hoi
AU  - She WH
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Tsang, Simon Hing-Yin
AU  - Tsang SH
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Lo, Chung Mau
AU  - Lo CM
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Man, Kwan
AU  - Man K
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Cheung, Tan To
AU  - Cheung TT
AD  - Department of Surgery, HKU-SZH & School of Clinical Medicine, Li Ka Shing Faculty 
      of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory 
      of Liver Research, The University of Hong Kong, Hong Kong, China. Electronic 
      address: cheung68@hku.hk.
LA  - eng
PT  - Journal Article
DEP - 20231020
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Hepatocellular/pathology
MH  - Granulocyte-Macrophage Colony-Stimulating Factor
MH  - *Liver Neoplasms/pathology
MH  - Cytokines
MH  - Interleukin-6
MH  - Interleukin-8
MH  - Retrospective Studies
MH  - Postoperative Complications/etiology
MH  - Hepatectomy/adverse effects
MH  - *Laparoscopy/adverse effects
MH  - Inflammation
MH  - Length of Stay
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - Inflammatory responses
OT  - Laparoscopic liver resection
OT  - Open liver resection
OT  - Postoperative cytokines
EDAT- 2023/10/31 00:42
MHDA- 2024/04/15 06:43
CRDT- 2023/10/30 22:59
PHST- 2023/04/20 00:00 [received]
PHST- 2023/10/06 00:00 [accepted]
PHST- 2024/04/15 06:43 [medline]
PHST- 2023/10/31 00:42 [pubmed]
PHST- 2023/10/30 22:59 [entrez]
AID - S1499-3872(23)00180-7 [pii]
AID - 10.1016/j.hbpd.2023.10.006 [doi]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2024 Jun;23(3):257-264. doi: 
      10.1016/j.hbpd.2023.10.006. Epub 2023 Oct 20.