PMID- 37904168
OWN - NLM
STAT- MEDLINE
DCOM- 20231101
LR  - 20231102
IS  - 1477-3155 (Electronic)
IS  - 1477-3155 (Linking)
VI  - 21
IP  - 1
DP  - 2023 Oct 31
TI  - PLGA nanoparticles engineering extracellular vesicles from human umbilical cord 
      mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic 
      osteolysis.
PG  - 398
LID - 10.1186/s12951-023-02177-7 [doi]
LID - 398
AB  - The wear particle-induced dissolution of bone around implants is a significant 
      pathological factor in aseptic loosening, and controlling prosthetic aseptic 
      loosening holds crucial social significance. While human umbilical cord 
      mesenchymal stem cell-derived exosomes (HucMSCs-Exos, Exos) have been found to 
      effectively promote osteogenesis and angiogenesis, their role in periprosthetic 
      osteolysis remains unexplored. To enhance their in vivo application, we 
      engineered HucMSCs-Exos-encapsulated poly lactic-co-glycolic acid (PLGA) 
      nanoparticles (PLGA-Exos). In our study, we demonstrate that PLGA-Exos stimulate 
      osteogenic differentiation while inhibiting the generation of reactive oxygen 
      species (ROS) and subsequent osteoclast differentiation in vitro. In vivo imaging 
      revealed that PLGA-Exos released exosomes slowly and maintained a therapeutic 
      concentration. Our in vivo experiments demonstrated that PLGA-Exos effectively 
      suppressed osteolysis induced by polyethylene particles. These findings suggest 
      that PLGA-Exos hold potential as a therapeutic approach for the prevention and 
      treatment of periprosthetic osteolysis. Furthermore, they provide novel insights 
      for the clinical management of osteolysis.
CI  - (c) 2023. The Author(s).
FAU - Xie, Jie
AU  - Xie J
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Hu, Yihe
AU  - Hu Y
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Su, Weiping
AU  - Su W
AD  - Department of Orthopaedics, The 3rd Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Chen, Sijie
AU  - Chen S
AD  - Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Wang, Jiahao
AU  - Wang J
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya 
      Road, Changsha, 410008, Hunan, China.
FAU - Liang, Shuailong
AU  - Liang S
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya 
      Road, Changsha, 410008, Hunan, China.
FAU - Chen, Mingyu
AU  - Chen M
AD  - Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Wang, Haoyi
AU  - Wang H
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya 
      Road, Changsha, 410008, Hunan, China.
FAU - Ma, Tianliang
AU  - Ma T
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya 
      Road, Changsha, 410008, Hunan, China. tianliangma@163.com.
LA  - eng
GR  - 81974339/the National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20231031
PL  - England
TA  - J Nanobiotechnology
JT  - Journal of nanobiotechnology
JID - 101152208
RN  - 9002-88-4 (Polyethylene)
RN  - 0 (Glycols)
SB  - IM
MH  - Humans
MH  - Osteogenesis
MH  - *Osteolysis/chemically induced/therapy
MH  - Polyethylene/adverse effects
MH  - Glycols/adverse effects
MH  - *Mesenchymal Stem Cells
MH  - *Exosomes
MH  - *Nanoparticles
MH  - Umbilical Cord
PMC - PMC10617042
OTO - NOTNLM
OT  - Aseptic loosening
OT  - Exosomes
OT  - Human umbilical cord derived mesenchymal stem cells
OT  - PLGA
OT  - Periprosthetic osteolysis
COIS- All other authors declare no competing interests.
EDAT- 2023/10/31 06:42
MHDA- 2023/11/01 12:44
PMCR- 2023/10/31
CRDT- 2023/10/31 00:51
PHST- 2023/05/10 00:00 [received]
PHST- 2023/10/26 00:00 [accepted]
PHST- 2023/11/01 12:44 [medline]
PHST- 2023/10/31 06:42 [pubmed]
PHST- 2023/10/31 00:51 [entrez]
PHST- 2023/10/31 00:00 [pmc-release]
AID - 10.1186/s12951-023-02177-7 [pii]
AID - 2177 [pii]
AID - 10.1186/s12951-023-02177-7 [doi]
PST - epublish
SO  - J Nanobiotechnology. 2023 Oct 31;21(1):398. doi: 10.1186/s12951-023-02177-7.