PMID- 37904206
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231103
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Oct 30
TI  - Assessment of left atrioventricular coupling and left atrial function impairment 
      in diabetes with and without hypertension using CMR feature tracking.
PG  - 295
LID - 10.1186/s12933-023-01997-z [doi]
LID - 295
AB  - PURPOSE: The study was designed to assess the effect of co-occurrence of diabetes 
      mellitus (DM) and hypertension on the deterioration of left atrioventricular 
      coupling index (LACI) and left atrial (LA) function in comparison to individuals 
      suffering from DM only. METHODS: From December 2015 to June 2022, we 
      consecutively recruited patients with clinically diagnosed DM who underwent 
      cardiac magnetic resonance (CMR) at our hospital. The study comprised a total of 
      176 patients with DM, who were divided into two groups based on their blood 
      pressure status: 103 with hypertension (DM + HP) and 73 without hypertension 
      (DM-HP). LA reservoir function (reservoir strain (epsilon(s)), total LA ejection 
      fraction (LAEF)), conduit function (conduit strain (epsilon(e)), passive LAEF), 
      booster-pump function (booster strain (epsilon(a)) and active LAEF), LA volume index 
      (LAVI), LV global longitudinal strain (LVGLS), and LACI were evaluated and 
      compared between the two groups. RESULTS: After adjusting for age, sex, body 
      surface area (BSA), and history of current smoking, total LAEF (61.16 +/- 14.04 vs. 
      56.05 +/- 12.72, p = 0.013) and active LAEF (43.98 +/- 14.33 vs. 38.72 +/- 13.51, 
      p = 0.017) were lower, while passive LAEF (33.22 +/- 14.11 vs. 31.28 +/- 15.01, 
      p = 0.807) remained unchanged in the DM + HP group compared to the DM-HP group. 
      The DM + HP group had decreased epsilon(s) (41.27 +/- 18.89 vs. 33.41 +/- 13.94, 
      p = 0.006), epsilon(e) (23.69 +/- 12.96 vs. 18.90 +/- 9.90, p = 0.037), epsilon(a) (17.83 +/- 8.09 
      vs. 14.93 +/- 6.63, p = 0.019), and increased LACI (17.40+/-10.28 vs. 22.72+/-15.01, 
      p = 0.049) when compared to the DM-HP group. In patients with DM, multivariate 
      analysis revealed significant independent associations between LV GLS and epsilons 
      (beta=-1.286, p < 0.001), epsilone (beta=-0.919, p < 0.001), and epsilona (beta=-0.324, p = 0.036). 
      However, there was no significant association observed between LV GLS and LACI 
      (beta=-0.003, p = 0.075). Additionally, hypertension was found to independently 
      contribute to decreased epsilona (beta=-2.508, p = 0.027) and increased LACI in 
      individuals with DM (beta = 0.05, p = 0.011). CONCLUSIONS: In DM patients, LV GLS 
      showed a significant association with LA phasic strain. Hypertension was found to 
      exacerbate the decline in LA booster strain and increase LACI in DM patients, 
      indicating potential atrioventricular coupling index alterations.
CI  - (c) 2023. The Author(s).
FAU - Shi, Rui
AU  - Shi R
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Jiang, Yi-Ning
AU  - Jiang YN
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Qian, Wen-Lei
AU  - Qian WL
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Guo, Ying-Kun
AU  - Guo YK
AD  - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of 
      Women and Children of Ministry of Education, West China Second University 
      Hospital, Sichuan University, Chengdu, China.
FAU - Gao, Yue
AU  - Gao Y
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Shen, Li-Ting
AU  - Shen LT
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Li, Xue-Ming
AU  - Li XM
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China. yangzg666@163.com.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu, 610041, Sichuan, China. dr.liyuan@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231030
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Humans
MH  - Atrial Function, Left
MH  - Heart Atria/diagnostic imaging
MH  - *Hypertension/complications/diagnosis/epidemiology
MH  - *Diabetes Mellitus/diagnosis/epidemiology/pathology
MH  - Magnetic Resonance Spectroscopy
PMC - PMC10617180
OTO - NOTNLM
OT  - Cardiac MRI
OT  - Cardiomyopathy
OT  - Diabetes mellitus
OT  - Hypertension
OT  - Left atrial dysfunction
COIS- The authors declare that they have no competing interests.
EDAT- 2023/10/31 06:42
MHDA- 2023/11/02 12:44
PMCR- 2023/10/30
CRDT- 2023/10/31 00:54
PHST- 2023/07/08 00:00 [received]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2023/11/02 12:44 [medline]
PHST- 2023/10/31 06:42 [pubmed]
PHST- 2023/10/31 00:54 [entrez]
PHST- 2023/10/30 00:00 [pmc-release]
AID - 10.1186/s12933-023-01997-z [pii]
AID - 1997 [pii]
AID - 10.1186/s12933-023-01997-z [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2023 Oct 30;22(1):295. doi: 10.1186/s12933-023-01997-z.