PMID- 37906138
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 40
IP  - 11
DP  - 2023 Nov 10
TI  - [Genetic analysis of two cases with MYC "negative" Burkitt lymphoma].
PG  - 1340-1344
LID - 10.3760/cma.j.cn511374-20220623-00422 [doi]
AB  - OBJECTIVE: To carry out combined genetic analysis on two patients suspected for 
      Burkitt lymphoma to facilitate their diagnosis and treatment. METHODS: G banded 
      karyotyping and interphase and metaphase fluorescence in situ hybridization 
      (FISH) were used to detect the specific sites of chromosomes by using separate 
      and fusion probes. RESULTS: The separate probe showed no presence of MYC gene 
      abnormality, while fusion probe confirmed the IGH::MYC translocation in the 
      samples. Combined with the clinical features and pathological characteristics, 
      the two patients were finally diagnosed with Burkitt lymphoma, which was 
      confirmed by targeted capture next generation sequencing. CONCLUSION: The 
      separate probe for the MYC gene has some shortcomings and should be used together 
      with dual fusion probe to improve the accuracy of diagnosis.
FAU - Lyu, Rui
AU  - Lyu R
AD  - Diagnosis and Treatment Center for Lymphoma, Hematology Hospital of Chinese 
      Academy of Medical Sciences (Institute of Hematology, Chinese Academy of Medical 
      Sciences), Tianjin 300020, China. lichengwen@ihcams.ac.cn.
FAU - Zheng, Yingchun
AU  - Zheng Y
FAU - An, Gang
AU  - An G
FAU - Li, Chengwen
AU  - Li C
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Humans
MH  - *Burkitt Lymphoma/genetics/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Genes, myc
MH  - Translocation, Genetic
MH  - Karyotyping
EDAT- 2023/10/31 12:41
MHDA- 2023/11/02 12:47
CRDT- 2023/10/31 11:12
PHST- 2023/11/02 12:47 [medline]
PHST- 2023/10/31 12:41 [pubmed]
PHST- 2023/10/31 11:12 [entrez]
AID - 940640228 [pii]
AID - 10.3760/cma.j.cn511374-20220623-00422 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2023 Nov 10;40(11):1340-1344. doi: 
      10.3760/cma.j.cn511374-20220623-00422.