PMID- 37908086
OWN - NLM
STAT- MEDLINE
DCOM- 20231201
LR  - 20231201
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 38
IP  - 1
DP  - 2024 Jan
TI  - Association Between Chronic Rhinosinusitis and Reflux Diseases in Adults: A 
      Systematic Review and Meta-Analysis.
PG  - 47-59
LID - 10.1177/19458924231210028 [doi]
AB  - BACKGROUND: Over the last few decades, reflux diseases, such as laryngopharyngeal 
      reflux (LPR) and gastroesophageal reflux disease (GERD), have been identified as 
      significant contributors to inflammatory upper aerodigestive tract diseases. 
      Establishing a direct relationship between reflux disease and chronic 
      rhinosinusitis (CRS) is challenging due to the high prevalence of both diseases 
      and their potential for independent coexistence. OBJECTIVE: The purpose of this 
      study is to review the existing literature and evaluate the evidence of an 
      association between reflux diseases and CRS. METHODS: A comprehensive electronic 
      search was conducted across multiple databases to identify all studies that 
      investigated the relationship between LPR, GERD, and CRS from January 1, 1950, to 
      June 16, 2022. Only studies with English manuscripts involving adult populations 
      were included, while case series, case reports, and in vitro studies were 
      excluded. The risk of bias was evaluated using The Newcastle-Ottawa Scale for 
      case-control studies and the NIH quality assessment tool for observational cohort 
      and cross-sectional studies. RESULTS: The search strategy yielded a total of 427 
      articles, out of which 25 studies examined the correlation between reflux 
      diseases and CRS. The meta-analysis indicated a significant association between 
      the presence of GERD and CRS compared to control groups (P < .001; CI 3.56 [2.25, 
      5.65]), as well as significantly higher pH values and pepsin detection in CRS 
      patients when compared to healthy individuals (P = .003). Furthermore, all 
      studies that evaluated proton pump inhibitor (PPI) therapy in CRS patients 
      reported positive outcomes, with 93% of CRS patients showing improvement on PPIs. 
      CONCLUSION: The existing literature provides suggestive evidence of an 
      association between reflux diseases and CRS, with regards to both prevalence and 
      treatment. Nonetheless, further studies are required to confirm this 
      relationship.
FAU - Aldajani, Ahmad
AU  - Aldajani A
AUID- ORCID: 0000-0001-8043-9096
AD  - Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia. RINGGOLD: 37850
AD  - Department of Otorhinolaryngology Head & Neck surgery, College of Medicine, 
      University of Jeddah, Jeddah, Saudi Arabia. RINGGOLD: 441424
FAU - Alhussain, Fahad
AU  - Alhussain F
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Mesallam, Tamer
AU  - Mesallam T
AD  - Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - AbaAlkhail, Mashal
AU  - AbaAlkhail M
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Alojayri, Raed
AU  - Alojayri R
AUID- ORCID: 0000-0001-5928-4974
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Bassam, Hashem
AU  - Bassam H
AUID- ORCID: 0009-0001-5156-7192
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Alotaibi, Omar
AU  - Alotaibi O
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Alqahtani, Mohammed
AU  - Alqahtani M
AD  - College of Medicine, King Saud university, Riyadh, Saudi Arabia. RINGGOLD: 37850
FAU - Alsaleh, Saad
AU  - Alsaleh S
AUID- ORCID: 0000-0002-1236-2098
AD  - Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia. RINGGOLD: 37850
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231031
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Rhinitis/complications
MH  - *Laryngopharyngeal Reflux/epidemiology/complications/diagnosis
MH  - Case-Control Studies
MH  - *Sinusitis/complications
MH  - Chronic Disease
MH  - Proton Pump Inhibitors
OTO - NOTNLM
OT  - anti-reflux
OT  - association
OT  - chronic rhinosinusitis
OT  - gastroesophageal reflux disease
OT  - laryngopharyngeal reflux
OT  - pH
OT  - pepsin
OT  - proton pump inhibitor
OT  - reflux diseases
OT  - rhinosinusitis
COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/11/01 06:43
MHDA- 2023/12/01 06:44
CRDT- 2023/11/01 03:39
PHST- 2023/12/01 06:44 [medline]
PHST- 2023/11/01 06:43 [pubmed]
PHST- 2023/11/01 03:39 [entrez]
AID - 10.1177/19458924231210028 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2024 Jan;38(1):47-59. doi: 10.1177/19458924231210028. Epub 
      2023 Oct 31.