PMID- 37909038
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240207
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 112
IP  - 1
DP  - 2024 Jan 3
TI  - Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in 
      male mice.
PG  - 113-123.e4
LID - S0896-6273(23)00752-3 [pii]
LID - 10.1016/j.neuron.2023.09.039 [doi]
AB  - Rehabilitation from alcohol addiction or abuse is hampered by withdrawal symptoms 
      including severe headaches, which often lead to rehabilitation failure. There is 
      no appropriate therapeutic option available for alcohol-withdrawal-induced 
      headaches. Here, we show the role of the mast-cell-specific receptor MrgprB2 in 
      the development of alcohol-withdrawal-induced headache. Withdrawing alcohol from 
      alcohol-acclimated mice induces headache behaviors, including facial allodynia, 
      facial pain expressions, and reduced movement, which are symptoms often observed 
      in humans. Those behaviors were absent in MrgprB2-deficient mice during alcohol 
      withdrawal. We observed in vivo spontaneous activation and hypersensitization of 
      trigeminal ganglia (TG) neurons in alcohol-withdrawal WT mice, but not in 
      alcohol-withdrawal MrgprB2-deficient mice. Increased mast cell degranulation by 
      alcohol withdrawal in dura mater was dependent on the presence of MrgprB2. The 
      results indicate that alcohol withdrawal causes headache via MrgprB2 of mast 
      cells in dura mater, suggesting that MrgprB2 is a potential target for treating 
      alcohol-withdrawal-related headaches.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Son, Hyeonwi
AU  - Son H
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Shannonhouse, John
AU  - Shannonhouse J
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Ishida, Hirotake
AU  - Ishida H
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Gomez, Ruben
AU  - Gomez R
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Kim, Yu Shin
AU  - Kim YS
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, University of 
      Texas Health Science Center at San Antonio, San Antonio, TX, USA; Programs in 
      Integrated Biomedical Sciences, Translational Sciences, Biomedical Engineering, 
      Radiological Sciences, University of Texas Health Science Center at San Antonio, 
      San Antonio, TX, USA. Electronic address: kimy1@uthscsa.edu.
LA  - eng
GR  - R01 DE026677/DE/NIDCR NIH HHS/United States
GR  - R01 DE031477/DE/NIDCR NIH HHS/United States
GR  - R01 NS128574/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20231030
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Male
MH  - Animals
MH  - Mast Cells/metabolism
MH  - *Alcoholism
MH  - *Substance Withdrawal Syndrome/complications/metabolism
MH  - Trigeminal Ganglion/physiology
MH  - Headache/metabolism
MH  - Receptors, G-Protein-Coupled/metabolism
PMC - PMC10843090
MID - NIHMS1936278
OTO - NOTNLM
OT  - CRF
OT  - GCaMP in vivo imaging
OT  - MrgprB2
OT  - alcohol use disorder
OT  - alcohol withdrawal
OT  - dura mater
OT  - headache
OT  - mast cell
OT  - pain
OT  - primary sensory neuron
OT  - trigeminal ganglia
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2023/11/01 06:43
MHDA- 2024/01/08 06:42
PMCR- 2025/01/03
CRDT- 2023/11/01 04:07
PHST- 2023/08/10 00:00 [received]
PHST- 2023/08/13 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2025/01/03 00:00 [pmc-release]
PHST- 2024/01/08 06:42 [medline]
PHST- 2023/11/01 06:43 [pubmed]
PHST- 2023/11/01 04:07 [entrez]
AID - S0896-6273(23)00752-3 [pii]
AID - 10.1016/j.neuron.2023.09.039 [doi]
PST - ppublish
SO  - Neuron. 2024 Jan 3;112(1):113-123.e4. doi: 10.1016/j.neuron.2023.09.039. Epub 
      2023 Oct 30.