PMID- 37909141
OWN - NLM
STAT- MEDLINE
DCOM- 20240125
LR  - 20240125
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 75
IP  - 5
DP  - 2023 Oct 25
TI  - [Research progress on the role and mechanism of endothelial dysfunction in 
      hyperhomocysteine-induced atherosclerosis].
PG  - 703-713
AB  - Hyperhomocysteinemia (HHcy) is considered to be an independent risk factor for 
      cardiovascular diseases, but the molecular mechanisms underlying its pathogenesis 
      are not fully understood. Endothelial dysfunction is a key initiating factor in 
      the pathogenesis of atherosclerosis, which is commonly observed in almost all 
      HHcy-induced vascular diseases. HHcy promotes oxidative stress, inhibits nitric 
      oxide production, suppresses hydrogen sulfide signaling pathway, promotes 
      endothelial mesenchymal transition, activates coagulation pathways, and promotes 
      protein N-homocysteination and cellular hypomethylation, all of which can cause 
      endothelial dysfunction. This article reviews the specific links between HHcy and 
      endothelial dysfunction, and highlights recent evidence that endothelial 
      mesenchymal transition contributes to HHcy-induced vascular damage, with a hope 
      to provide new ideas for the clinical treatment of HHcy-related vascular 
      diseases.
FAU - Wu, Cheng-Yan
AU  - Wu CY
AD  - Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical 
      University; Heart Center of Xinxiang Medical University, Xinxiang 453100, China.
FAU - Duan, Xu-Lei
AU  - Duan XL
AD  - Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical 
      University; Heart Center of Xinxiang Medical University, Xinxiang 453100, China.
FAU - Wang, Li-Bo
AU  - Wang LB
AD  - Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical 
      University; Heart Center of Xinxiang Medical University, Xinxiang 453100, China.
FAU - Wang, Xue-Hui
AU  - Wang XH
AD  - Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical 
      University; Heart Center of Xinxiang Medical University, Xinxiang 453100, China. 
      121045@xxmu.edu.cn.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Humans
MH  - *Atherosclerosis
MH  - *Cardiovascular Diseases
MH  - Endothelium, Vascular
MH  - Homocysteine/metabolism
MH  - *Hyperhomocysteinemia/complications
MH  - Oxidative Stress
MH  - Risk Factors
EDAT- 2023/11/01 06:43
MHDA- 2023/11/02 12:43
CRDT- 2023/11/01 04:33
PHST- 2023/11/02 12:43 [medline]
PHST- 2023/11/01 06:43 [pubmed]
PHST- 2023/11/01 04:33 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2023 Oct 25;75(5):703-713.