PMID- 37910577
OWN - NLM
STAT- MEDLINE
DCOM- 20231128
LR  - 20231128
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 17
IP  - 11
DP  - 2023 Nov
TI  - Tumor necrosis factor-alpha (TNF-alpha) -308G >a promoter polymorphism (rs1800629) 
      promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A 
      meta-analysis.
PG  - e0011735
LID - 10.1371/journal.pntd.0011735 [doi]
LID - e0011735
AB  - The multifactorial pathogenesis of severe malaria is partly attributed to host 
      genes, such as those encoding cytokines involved in complex inflammatory 
      reactions, namely tumor necrosis factor-alpha (TNF-alpha). However, the relationship 
      between TNF-alpha -308G >A gene polymorphism (rs1800629) and the severity of 
      Plasmodium falciparum (P. falciparum) malaria remains unclear, which prompts a 
      meta-analysis to obtain more precise estimates. The present meta-analysis aimed 
      to better understand this correlation and provide insight into its association in 
      populations with different ethnicities. Literature search outcomes included eight 
      eligible articles in which TNF-alpha -308G >A polymorphism was determined in 
      uncomplicated malaria (UM) and severe malaria (SM) of P. falciparum as 
      represented in the case and control groups. Pooled odds ratios (ORs) and 95% 
      confidence intervals (95% CIs) were estimated in standard homozygous, recessive, 
      dominant, and codominant genetic models. Subgroup analysis was based on 
      ethnicity, i.e., Africans and Asians. The analyses included overall and the 
      modified outcomes; the latter was obtained without the studies that deviated from 
      the Hardy-Weinberg Equilibrium. The significant data also underwent sensitivity 
      treatment but not publication bias tests because the number of studies was less 
      than ten. Interaction tests were applied to differential outcomes between the 
      subgroups. Overall and HWE-compliant analyses showed no significant association 
      between the TNF-alpha -308G >A polymorphism and susceptibility to P. falciparum SM 
      (ORs = 1.10-1.52, 95%CIs = 0.68-2.79; Pa = 0.24-0.68). Stratification by 
      ethnicity revealed that two significant associations were found only in the 
      Asians favoring SM for dominant (OR = 1.95, 95% CI = 1.06-3.61, Pa = 0.03) and 
      codominant (OR = 1.83, 95% CI = 1.15-2.92, Pa = 0.01) under the random-effects 
      model, but not among the African populations. The two significant Asian 
      associations were improved with a test of interaction with P-value of0.02-0.03. 
      The significant core outcomes were robust. Results of the meta-analysis suggest 
      that TNF-alpha -308G >A polymorphism might affect the risk of P. falciparum SM, 
      particularly in individuals of Asian descent. This supports ethnicity as one of 
      the dependent factors of the TNF-alpha -308G >A association with the clinical 
      severity of malaria. Further large and well-designed genetic studies are needed 
      to confirm this conclusion.
CI  - Copyright: (c) 2023 Kongjam et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Kongjam, Panida
AU  - Kongjam P
AD  - Chulabhorn International College of Medicine, Thammasat University (Rangsit 
      Campus), Klongneung, Klongluang, Pathumthani, Thailand.
FAU - Pabalan, Noel
AU  - Pabalan N
AD  - Chulabhorn International College of Medicine, Thammasat University (Rangsit 
      Campus), Klongneung, Klongluang, Pathumthani, Thailand.
FAU - Tharabenjasin, Phuntila
AU  - Tharabenjasin P
AD  - Chulabhorn International College of Medicine, Thammasat University (Rangsit 
      Campus), Klongneung, Klongluang, Pathumthani, Thailand.
FAU - Jarjanazi, Hamdi
AU  - Jarjanazi H
AD  - Environmental Monitoring and Reporting Branch, Ontario Ministry of the 
      Environment and Parks, Toronto, Ontario, Canada.
FAU - Chaijaroenkul, Wanna
AU  - Chaijaroenkul W
AD  - Chulabhorn International College of Medicine, Thammasat University (Rangsit 
      Campus), Klongneung, Klongluang, Pathumthani, Thailand.
FAU - Na-Bangchang, Kesara
AU  - Na-Bangchang K
AUID- ORCID: 0000-0001-6389-0897
AD  - Chulabhorn International College of Medicine, Thammasat University (Rangsit 
      Campus), Klongneung, Klongluang, Pathumthani, Thailand.
AD  - Graduate Program in Bioclinical Sciences, Chulabhorn International College of 
      Medicine, Thammasat University (Rangsit Campus), Klongnueng, Klongluang, 
      Pathumthani, Thailand.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20231101
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (TNF protein, human)
SB  - IM
MH  - Humans
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Plasmodium falciparum/genetics
MH  - Polymorphism, Single Nucleotide
MH  - *Tumor Necrosis Factor-alpha/genetics
PMC - PMC10655976
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/11/01 18:43
MHDA- 2023/11/27 12:44
PMCR- 2023/11/01
CRDT- 2023/11/01 13:53
PHST- 2023/05/16 00:00 [received]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/11/17 00:00 [revised]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/11/01 18:43 [pubmed]
PHST- 2023/11/01 13:53 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - PNTD-D-23-00589 [pii]
AID - 10.1371/journal.pntd.0011735 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2023 Nov 1;17(11):e0011735. doi: 
      10.1371/journal.pntd.0011735. eCollection 2023 Nov.