PMID- 37914223
OWN - NLM
STAT- MEDLINE
DCOM- 20231103
LR  - 20231229
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Print)
IS  - 1180-4882 (Linking)
VI  - 48
IP  - 6
DP  - 2023 Nov-Dec
TI  - Beyond verbal fluency in the verbal fluency task: semantic clustering as a 
      predictor of remission in individuals at clinical high risk for psychosis.
PG  - E414-E420
LID - 10.1503/jpn.230074 [doi]
AB  - BACKGROUND: There have been conflicting reports on whether conventional verbal 
      fluency measures can predict the prognosis of individuals at clinical high risk 
      (CHR) for psychosis. We aimed to investigate whether verbal fluency task measures 
      that represent semantic processing more directly than conventional measures could 
      be more reliable predictors of later remission in CHR individuals. METHODS: We 
      recruited CHR individuals and healthy controls to participate in a baseline 
      verbal fluency assessment. We identified semantic clusters within the verbal 
      fluency task responses based on cosine similarity between consecutive words, 
      calculated from the word embedding model. Binomial logistic regression was 
      performed to test whether average semantic cluster size and number of words 
      produced could be predictors of remission in CHR individuals. RESULTS: Our study 
      sample included 96 CHR individuals and 178 healthy controls. According to 
      clinical assessment at the last follow-up, 23 CHR individuals were classified as 
      remitters and 73 as nonremitters, including 29 individuals who converted to 
      psychosis. The CHR remitters showed larger average and maximum semantic cluster 
      sizes than CHR nonremitters and healthy controls. Average semantic cluster size, 
      but not the number of words, was a significant predictor of later remission in 
      CHR individuals. LIMITATIONS: Our sample included only native Korean speakers. 
      CONCLUSION: A verbal fluency task measure that more specifically represents 
      semantic processing may be a better neurocognitive predictive marker for 
      remission in CHR individuals than conventional verbal fluency measures. Our 
      results provide an explanation for heterogeneous reports on whether verbal 
      fluency can predict prognosis in CHR individuals and suggest that semantic 
      processing is a putative cognitive predictor of their prognosis.
CI  - (c) 2023 CMA Impact Inc. or its licensors.
FAU - Choe, Eugenie
AU  - Choe E
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
FAU - Ha, Minji
AU  - Ha M
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
FAU - Choi, Sunah
AU  - Choi S
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
FAU - Park, Sunghyun
AU  - Park S
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
FAU - Jang, Moonyoung
AU  - Jang M
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
FAU - Kim, Minah
AU  - Kim M
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon) verte82@snu.ac.kr.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - From the Department of Neuropsychiatry, Seoul National University Hospital, 
      Seoul, Republic of Korea (Choe, Park, Jang, Kim, Kwon); the Department of 
      Psychiatry, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe, Park, Jang, Kim, Kwon); the Department of Clinical Pharmacology and 
      Therapeutics, Seoul National University College of Medicine, Seoul, Republic of 
      Korea (Choe); the Department of Brain and Cognitive Sciences, Seoul National 
      University College of Natural Sciences, Seoul, Republic of Korea (Ha, Choi, 
      Kwon); the Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of 
      Korea (Kwon).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231101
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
SB  - IM
MH  - Humans
MH  - *Semantics
MH  - Neuropsychological Tests
MH  - *Psychotic Disorders
MH  - Prognosis
MH  - Cluster Analysis
PMC - PMC10620004
COIS- Competing interests: None declared.
EDAT- 2023/11/02 00:42
MHDA- 2023/11/03 06:44
PMCR- 2023/11/01
CRDT- 2023/11/01 20:43
PHST- 2023/05/14 00:00 [received]
PHST- 2023/07/12 00:00 [revised]
PHST- 2023/08/04 00:00 [revised]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/11/03 06:44 [medline]
PHST- 2023/11/02 00:42 [pubmed]
PHST- 2023/11/01 20:43 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - 48/6/E414 [pii]
AID - 48-6-E414 [pii]
AID - 10.1503/jpn.230074 [doi]
PST - epublish
SO  - J Psychiatry Neurosci. 2023 Nov 1;48(6):E414-E420. doi: 10.1503/jpn.230074. Print 
      2023 Nov-Dec.