PMID- 37914556 OWN - NLM STAT- Publisher LR - 20231101 IS - 2531-0437 (Electronic) IS - 2531-0429 (Linking) DP - 2023 Oct 30 TI - Transbronchial lung cryobiopsy for peripheral pulmonary lesions. A narrative review. LID - S2531-0437(23)00163-0 [pii] LID - 10.1016/j.pulmoe.2023.08.010 [doi] AB - An increasing number of peripheral pulmonary lesions (PPLs) requiring tissue verification to establish a definite diagnosis for further individualized management are detected due to the growing adoption of lung cancer screening by chest computed tomography (CT), especially low-dose CT. However, the morphological diagnosis of PPLs remains challenging. Transbronchial lung cryobiopsy (TBLC) that can retrieve larger specimens with more preserved cellular architecture and fewer crush artifacts in comparison with conventional transbronchial forceps biopsy (TBFB), as an emerging technology for diagnosing PPLs, has been demonstrated to have the potential to resolve the clinical dilemma pertaining to currently available sampling devices (e.g., forceps, needle and brush) and become a diagnostic cornerstone for PPLs. Of note, with the introduction of the 1.1 mm cryoprobe that will be more compatible with advanced bronchoscopic navigation techniques, such as radial endobronchial ultrasound (r-EBUS), virtual bronchoscopic navigation (VBN) and electromagnetic navigation bronchoscopy (ENB), the use of TBLC is expected to gain more popularity in the diagnosis of PPLs. While much remains for exploration using the TBLC technique for diagnosing PPLs, it can be envisaged that the emergence of additional studies with larger data accrual will hopefully add to the body of evidence in this field. CI - Copyright (c) 2023 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Tang, Yilian AU - Tang Y AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China; Department of Respiratory and Critical Care Medicine, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, China; Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. FAU - Tian, Sen AU - Tian S AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China; Department of Respiratory and Critical Care Medicine, No. 906 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Ningbo, China. FAU - Chen, Hui AU - Chen H AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China; Department of Respiratory and Critical Care Medicine, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan, China. FAU - Li, Xiang AU - Li X AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China; Department of Respiratory and Critical Care Medicine, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan, China. FAU - Pu, Xiang AU - Pu X AD - Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. FAU - Zhang, Xiaoqin AU - Zhang X AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. FAU - Zheng, Yan AU - Zheng Y AD - Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China. FAU - Li, Yonghua AU - Li Y AD - Department of Respiratory and Critical Care Medicine, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan, China. FAU - Huang, Haidong AU - Huang H AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China. FAU - Bai, Chong AU - Bai C AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China. Electronic address: Chongbai@smmu.edu.cn. LA - eng PT - Journal Article PT - Review DEP - 20231030 PL - Spain TA - Pulmonology JT - Pulmonology JID - 101723786 SB - IM OTO - NOTNLM OT - Diagnosis OT - Lung cancer OT - Peripheral pulmonary lesions OT - Radial endobronchial ultrasound OT - Transbronchial lung cryobiopsy COIS- Conflicts of interest The authors declare no competing interest. EDAT- 2023/11/02 00:42 MHDA- 2023/11/02 00:42 CRDT- 2023/11/01 22:57 PHST- 2023/08/07 00:00 [received] PHST- 2023/08/24 00:00 [revised] PHST- 2023/08/30 00:00 [accepted] PHST- 2023/11/02 00:42 [medline] PHST- 2023/11/02 00:42 [pubmed] PHST- 2023/11/01 22:57 [entrez] AID - S2531-0437(23)00163-0 [pii] AID - 10.1016/j.pulmoe.2023.08.010 [doi] PST - aheadofprint SO - Pulmonology. 2023 Oct 30:S2531-0437(23)00163-0. doi: 10.1016/j.pulmoe.2023.08.010.