PMID- 37914665
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 20
IP  - 10
DP  - 2024 Mar
TI  - Ingenious Synergy of a Pathology-Specific Biomimetic Multifunctional Nanoplatform 
      for Targeted Therapy in Rheumatoid Arthritis.
PG  - e2305197
LID - 10.1002/smll.202305197 [doi]
AB  - Based on the pathological characteristics of rheumatoid arthritis, including the 
      overproduction of reactive oxygen species (ROS), inflammatory responses, and 
      osteoclast differentiation, a biomimetic multifunctional nanomedicine (M-M@I) is 
      designed. Iguratimod (IGU) is loaded, which inhibits inflammatory responses and 
      osteoclast differentiation, into mesoporous polydopamine (MPDA), which scavenges 
      ROS. Subsequently, the nanoparticles are coated with a cell membrane of 
      macrophages to achieve actively targeted delivery of the nanoparticles to 
      inflamed joints. It is shown that the M-M@I nanoparticles are taken up well by 
      lipopolysaccharide-induced RAW 264.7 macrophages or bone marrow-derived 
      macrophages (BMDMs). In vitro, the M-M@I nanoparticles effectively scavenge ROS, 
      downregulate genes related to inflammation promotion and osteoclast 
      differentiation, and reduce the proinflammatory cytokines and osteoclast-related 
      enzymes. They also reduce the polarization of macrophages to a pro-inflammatory 
      M1 phenotype and inhibit differentiation into osteoclasts. In mice with 
      collagen-induced arthritis, the M-M@I nanoparticles accumulate at arthritic sites 
      and circulate longer, significantly mitigating arthritis symptoms and bone 
      destruction. These results suggest that the pathology-specific biomimetic 
      multifunctional nanoparticles are effective against rheumatoid arthritis, and 
      they validate the approach of developing multifunctional therapies that target 
      various pathological processes simultaneously.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Xu, Hong
AU  - Xu H
AUID- ORCID: 0000-0002-7905-0873
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Wang, Yuemin
AU  - Wang Y
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu, 610065, China.
FAU - Rong, Xiao
AU  - Rong X
AD  - Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 
      610041, China.
FAU - Wang, Duan
AU  - Wang D
AUID- ORCID: 0000-0001-5487-4414
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Xie, Jinwei
AU  - Xie J
AUID- ORCID: 0000-0002-0623-6036
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Huang, Zeyu
AU  - Huang Z
AUID- ORCID: 0000-0002-0456-8379
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Zeng, Weinan
AU  - Zeng W
AUID- ORCID: 0000-0002-3952-1968
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Fu, Xiaoxue
AU  - Fu X
AUID- ORCID: 0009-0007-7113-9607
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
FAU - Li, Jianshu
AU  - Li J
AD  - College of Polymer Science and Engineering, State Key Laboratory of Polymer 
      Materials Engineering, Sichuan University, Chengdu, 610065, China.
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Med-X 
      Center for Materials, Sichuan University, Chengdu, 610041, China.
FAU - Zhou, Zongke
AU  - Zhou Z
AUID- ORCID: 0000-0002-9037-4756
AD  - Department of Orthopedic Surgery and Orthopedic Research Institution, West China 
      Hospital, Sichuan University, Chengdu, 610041, China.
LA  - eng
GR  - 82172394/National Natural Science Foundation of China/
GR  - U22A20280/National Natural Science Foundation of China/
GR  - 82102542/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20231101
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Reactive Oxygen Species/metabolism
MH  - Biomimetics
MH  - *Arthritis, Rheumatoid/drug therapy/metabolism/pathology
MH  - Osteoclasts
MH  - Macrophages/metabolism
MH  - *Arthritis, Experimental/metabolism/pathology
OTO - NOTNLM
OT  - bone erosion
OT  - inflammation
OT  - reactive oxygen species
OT  - rheumatoid arthritis
OT  - targeted therapy
EDAT- 2023/11/02 00:43
MHDA- 2024/03/11 06:43
CRDT- 2023/11/01 23:02
PHST- 2023/10/11 00:00 [revised]
PHST- 2023/06/21 00:00 [received]
PHST- 2024/03/11 06:43 [medline]
PHST- 2023/11/02 00:43 [pubmed]
PHST- 2023/11/01 23:02 [entrez]
AID - 10.1002/smll.202305197 [doi]
PST - ppublish
SO  - Small. 2024 Mar;20(10):e2305197. doi: 10.1002/smll.202305197. Epub 2023 Nov 1.