PMID- 37914963
OWN - NLM
STAT- Publisher
LR  - 20231102
IS  - 1559-0291 (Electronic)
IS  - 0273-2289 (Linking)
DP  - 2023 Nov 2
TI  - Systemic analysis of the prognostic significance and interaction network of 
      miR-26b-3p in cholangiocarcinoma.
LID - 10.1007/s12010-023-04753-x [doi]
AB  - MicroRNAs (miRNAs) reportedly play significant roles in the progression of 
      various cancers and hold huge potential as both diagnostic tools and therapeutic 
      targets. Given the ongoing uncertainty surrounding the precise functions of 
      several miRNAs in cholangiocarcinoma (CCA), this research undertakes a 
      comprehensive analysis of CCA data sourced from Gene Expression Omnibus (GEO) and 
      The Cancer Genome Atlas (TCGA) databases. The present study identified a novel 
      miRNA, specifically miR-26b-3p, which exhibited prognostic value for individuals 
      with CCA. Notably, miR-26b-3p was upregulated within CCA samples, with an inverse 
      correlation established with patient prognosis (Hazard Ratio = 8.19, p = 0.018). 
      Through a combination of functional enrichment analysis, analysis of the 
      LncRNA-miR-26b-3p-mRNA interaction network, and validation by qRT PCR and western 
      blotting, this study uncovered the potential of miR-26b-3p in potentiating the 
      malignant progression of CCA via regulation of essential genes (including PSMD14, 
      XAB2, SLC4A4) implicated in processes such as endoplasmic reticulum (ER) stress 
      and responses to misfolded proteins. Our findings introduce novel and valuable 
      insights that position miR-26b-3p-associated genes as promising biomarkers for 
      the diagnosis and treatment of CCA.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Yan, Xijing
AU  - Yan X
AD  - Department of Hepatic Surgery and Liver Transplantation Center, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
AD  - Department of Breast and Thyroid Surgery, Lingnan Hospital, The Third Affiliated 
      Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
FAU - Hu, Zhongying
AU  - Hu Z
AD  - Guangdong Provincial Key Laboratory of Liver Disease Research, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
FAU - Li, Xuejiao
AU  - Li X
AD  - Guangdong Provincial Key Laboratory of Liver Disease Research, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
FAU - Liang, Jinliang
AU  - Liang J
AD  - Guangdong Provincial Key Laboratory of Liver Disease Research, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
FAU - Zheng, Jun
AU  - Zheng J
AD  - Department of Hepatic Surgery and Liver Transplantation Center, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.
FAU - Gong, Jiao
AU  - Gong J
AD  - Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, 510630, China.
FAU - Hu, Kunpeng
AU  - Hu K
AD  - Department of Breast and Thyroid Surgery, Lingnan Hospital, The Third Affiliated 
      Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. 
      hukpeng@mail.sysu.edu.cn.
FAU - Sui, Xin
AU  - Sui X
AD  - Surgical ICU, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 
      510630, China. drsuixin@126.com.
FAU - Li, Rong
AU  - Li R
AUID- ORCID: 0000-0003-4951-577X
AD  - Guangdong Provincial Key Laboratory of Liver Disease Research, The Third 
      Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. 
      Lirong53@mail.sysu.edu.cn.
LA  - eng
GR  - 81802897/National Natural Science Foundation of China/
GR  - 81901943/National Natural Science Foundation of China/
GR  - 2021A1515011156/Natural Science Foundation of Guangdong Province/
GR  - 202102020237/Basic and Applied Basic Research Foundation of Guangdong Province/
GR  - 2020B1212060019/Guangdong Key Laboratory of Liver Disease Research/
GR  - SL2022A03J01381/Guangzhou Basic and Applied Basic Research Project Co-funded by 
      Municipal Schools (institutes)/
PT  - Journal Article
DEP - 20231102
PL  - United States
TA  - Appl Biochem Biotechnol
JT  - Applied biochemistry and biotechnology
JID - 8208561
SB  - IM
OTO - NOTNLM
OT  - Cholangiocarcinoma
OT  - Functional enrichment analysis
OT  - LncRNAs-miR-26b-3p-mRNAs network
OT  - MiR-26b-3p
OT  - Prognostic and diagnostic markers
EDAT- 2023/11/02 06:43
MHDA- 2023/11/02 06:43
CRDT- 2023/11/02 00:41
PHST- 2023/10/17 00:00 [accepted]
PHST- 2023/11/02 06:43 [medline]
PHST- 2023/11/02 06:43 [pubmed]
PHST- 2023/11/02 00:41 [entrez]
AID - 10.1007/s12010-023-04753-x [pii]
AID - 10.1007/s12010-023-04753-x [doi]
PST - aheadofprint
SO  - Appl Biochem Biotechnol. 2023 Nov 2. doi: 10.1007/s12010-023-04753-x.