PMID- 37915473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 12
IP  - 5
DP  - 2023 Oct
TI  - 2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing 
      atypical ultrasonic vocalization in infant mice.
PG  - 999-1004
LID - 10.1093/toxres/tfad069 [doi]
AB  - Epidemiological and experimental studies indicate that maternal exposure to 
      environmental pollutants impairs the cognitive and motor functions of offspring 
      in humans and laboratory animals. Infant ultrasonic vocalizations (USVs), the 
      communicative behavior of pups toward caregivers, are impaired in rodent models 
      of neurodevelopmental disorders, suggesting a useful method to evaluate the 
      developmental neurotoxicity of environmental pollutants. Therefore, we 
      investigated USVs emitted by mouse pups of dams exposed to 
      2-chloro-3,7,8-tribromodibenzofuran (TeXDF) and 1,2,3,7,8-pentabromodibenzofuran 
      (PeBDF), which are detected in the actual environment. The USV duration and 
      number in the pups born to dams administered with TeXDF 40 mug/kg body weight 
      (b.w.), but not 8 mug/kg b.w., on gestational day (GD) 12.5, were significantly 
      lower than those in the corresponding pups on postnatal days 3-9. Conversely, 
      there was no statistical change in the USVs emitted by the pups of dams 
      administered with PeBDF 35 or 175 mug/kg b.w. on GD 12.5. To examine whether 
      maternal exposure leads to behavioral impairments in adulthood, we analyzed 
      exploratory behaviors in a novel environment using IntelliCage, a fully automated 
      testing apparatus for group-housed mice. Neither TeXDF nor PeBDF exposure induced 
      significant differences in offspring exploration. Considered together, our 
      findings revealed that TeXDF induces atypical USV emission in infant mice, 
      suggesting the importance of further studies on the risk assessment of mixed 
      brominated/chlorinated dibenzo-p-dioxins and dibenzofurans.
CI  - (c) The Author(s) 2023. Published by Oxford University Press.
FAU - Kimura, Eiki
AU  - Kimura E
AUID- ORCID: 0000-0001-7164-8099
AD  - Health and Environmental Risk Research Division, National Institute for 
      Environmental Studies, Tsukuba 305-8506, Japan.
AD  - Japan Society for the Promotion of Science, Tokyo 102-0083, Japan.
AD  - Department of Environmental Health, University of Fukui School of Medical 
      Sciences, Fukui 910-1193, Japan.
FAU - Suzuki, Go
AU  - Suzuki G
AUID- ORCID: 0000-0002-4001-5632
AD  - Material Cycles Division, National Institute for Environmental Studies, Tsukuba 
      305-8506, Japan.
FAU - Uramaru, Naoto
AU  - Uramaru N
AUID- ORCID: 0000-0001-8245-8100
AD  - Division of Pharmaceutical Health Biosciences, Nihon Pharmaceutical University, 
      Saitama 362-0806, Japan.
FAU - Kakeyama, Masaki
AU  - Kakeyama M
AUID- ORCID: 0000-0001-9063-9673
AD  - Faculty of Human Sciences, Waseda University, Saitama 359-1192, Japan.
FAU - Maekawa, Fumihiko
AU  - Maekawa F
AUID- ORCID: 0000-0002-1762-8270
AD  - Health and Environmental Risk Research Division, National Institute for 
      Environmental Studies, Tsukuba 305-8506, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230823
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC10615804
OTO - NOTNLM
OT  - developmental neurotoxicity
OT  - mixed polybrominated/chlorinated dibenzofuran
OT  - mouse
OT  - ultrasonic vocalization
EDAT- 2023/11/02 06:42
MHDA- 2023/11/02 06:43
PMCR- 2023/08/23
CRDT- 2023/11/02 03:57
PHST- 2023/04/01 00:00 [received]
PHST- 2023/07/22 00:00 [revised]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/11/02 06:43 [medline]
PHST- 2023/11/02 06:42 [pubmed]
PHST- 2023/11/02 03:57 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - tfad069 [pii]
AID - 10.1093/toxres/tfad069 [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2023 Aug 23;12(5):999-1004. doi: 10.1093/toxres/tfad069. 
      eCollection 2023 Oct.